Product Name: 2-(3,4-Epoxycyclohexyl)Ethyltrimethoxysilane
Chemical Formula: C13H24O4Si
CAS Number: 3388-04-3
Synonyms: 3,4-Epoxycyclohexylmethyltrimethoxysilane; Epoxy-functional silane
Recommended Use: Coupling agent, adhesion promoter in coatings, sealants, adhesives
Manufacturer Name: Supplier information available upon request
Emergency Contact: Emergency response services (local or national)
UN Number: 2810 (for transport emergencies involving toxic liquids, organic, n.o.s.)
GHS Classification: Skin Irritation Category 2; Eye Irritation Category 2A; Sensitizer—skin Category 1; Target Organ Toxicity—single exposure Category 3
Hazard Pictograms: GHS07 (Exclamation Mark)
Signal Word: Warning
Hazard Statements: Causes skin irritation. Causes serious eye irritation. May cause allergic skin reaction. May cause respiratory irritation on direct inhalation.
Precautionary Statements: Avoid breathing vapors or mist. Wear protective gloves, safety goggles, and chemical-resistant clothing. Wash skin thoroughly after use. If exposed or concerned, seek medical help.
Routes of Exposure: Inhalation, skin and eye contact
Symptoms: Redness, itching, dry or cracked skin; stinging and tearing in eyes; shortness of breath, sore throat if inhaled
Main Ingredient: 2-(3,4-Epoxycyclohexyl)Ethyltrimethoxysilane (CAS: 3388-04-3; Purity > 96%)
Impurities: Trace organic solvents or siloxanes possible (specific identities confidential or negligible under OSHA/HCS regulations)
Other Constituents: No additional hazardous components present above reportable thresholds.
Inhalation: Move affected person outdoors. Seek medical advice if breathing is difficult or symptoms persist. Support breathing with oxygen as needed.
Skin Contact: Remove contaminated clothing. Rinse exposed area thoroughly with water and mild soap for at least 20 minutes. Get medical attention for persistent irritation.
Eye Contact: Rinse eyes with lukewarm water for at least 15 minutes, holding eyelids open. Remove contact lenses if present and easy. Immediate medical attention recommended.
Ingestion: Do not induce vomiting. Rinse mouth with water and seek immediate medical attention. Never give anything by mouth to an unconscious person.
Symptomatic Treatment: Treat based on symptoms. Observation recommended for respiratory or allergic response.
Suitable Extinguishing Media: Carbon dioxide, dry chemical extinguishers, foam, or water spray. Do not use water jet directly as it may spread the burning liquid.
Special Hazards: Vapors may form explosive mixtures with air. Burning product may produce carbon monoxide, carbon dioxide, silicon oxides, organic vapors.
Firefighter Protection: Wear self-contained breathing apparatus and full protective gear. Keep containers cool with water spray.
Combustion Products: Carbon oxides, silicon dioxide, incompletely burned hydrocarbons.
Advice for Firefighters: Avoid runoff from fire control contaminating waterways or sewers.
Personal Precautions: Isolate spill area. Wear chemical splash goggles, impervious gloves, chemical-resistant apron, and appropriate respiratory protection.
Environmental Precautions: Prevent further leakage or spillage. Do not allow to enter drains, groundwater, or surface water. Notify authorities in case of major environmental impact or uncontrolled releases.
Containment Methods: Dike and contain with inert absorbent (sand, earth, vermiculite, diatomaceous earth). Avoid using combustibles like sawdust.
Cleanup: Soak up and collect residue in suitable containers for proper disposal. Ventilate affected area.
Other Measures: Decontaminate tools and area after cleanup.
Handling Practices: Use with proper ventilation in areas free from ignition sources. Do not breathe vapors or handle without recommended PPE. Keep containers tightly closed when not in use. Avoid contact with skin, eyes, and clothing.
Storage Conditions: Store in cool, dry, well-ventilated space. Protect from heat, sparks, or open flame. Keep container tightly sealed, away from incompatible chemicals (acids, bases, oxidizers). Recommended storage temperature: below 30°C (86°F).
Transfer Precautions: Ground or bond containers when transferring liquid to avoid static discharge.
Special Instructions: Label storage clearly, train personnel on chemical hazards and proper response.
Engineering Controls: Handle in well-ventilated areas or use local exhaust. Use closed systems where possible to minimize vapor release.
Eye Protection: Chemical safety goggles or full face shield
Skin Protection: Impervious gloves (nitrile, neoprene), long sleeves, chemical-resistant apron
Respiratory Protection: Organic vapor respirator for low-level exposure; self-contained breathing apparatus for high concentrations or spills
Workplace Hygiene: Wash hands and exposed areas with soap and water before eating, drinking, or using the bathroom. Take off contaminated clothing and wash before reuse.
Exposure Limits: No specific occupational exposure limit for this compound; control workplace exposure via engineering measures and safe practices.
Appearance: Clear, colorless to pale yellow liquid
Odor: Mild, ether-like
pH: Not applicable (non-aqueous)
Boiling Point: 274–276°C (525–529°F)
Melting Point: Below -50°C (-58°F)
Flash Point: 115°C (239°F) closed cup
Vapor Pressure: 0.09 mmHg at 25°C
Vapor Density: Approx. 1 (air = 1)
Solubility: Partially hydrolyzes in water, soluble in organic solvents (alcohols, ketones)
Density: 1.07–1.10 g/cm³ at 20°C
Viscosity: 6–8 cP at 25°C
Evaporation Rate: Much slower than ether
Partition Coefficient (n-octanol/water): Not available
Autoignition Temperature: > 300°C (572°F)
Chemical Stability: Stable under recommended storage and handling conditions. Decomposes on exposure to heat or moisture over time.
Reactivity: Hydrolyzes slowly to form methanol and silanols in presence of water. Exothermic reaction may occur on contact with acids or bases.
Conditions to Avoid: Excess heat, direct sunlight, water or humid air, strong acids and bases, sources of ignition.
Hazardous Reactions: No polymerization under normal conditions.
Incompatible Materials: Strong oxidizing agents, aqueous acid/alkali, water (slow hydrolysis).
Decomposition Products: Methanol, formaldehyde, carbon oxides, silicon oxides.
Likely Routes of Exposure: Inhalation, eye and skin contact, incidental ingestion
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg; Dermal LD50 (rabbit): >2000 mg/kg; no severe acute toxicity recorded at industrial handling levels.
Skin Corrosion/Irritation: Causes moderate to severe irritation.
Eye Damage/Irritation: Causes moderate to severe irritation.
Respiratory Sensitization: No sensitizing effects observed in animal studies, but vapor and aerosols may irritate respiratory tract.
Skin Sensitization: Potential to cause allergic skin reaction, avoid repeated or prolonged contact.
Chronic Effects: Chronic exposure may cause dermatitis, respiratory irritation, allergy development.
Carcinogenicity: Not classified as carcinogenic by IARC, OSHA, NTP. Methanol (byproduct of hydrolysis) is a toxic, non-carcinogenic compound.
Mutagenicity: No data indicating mutagenic effects.
Reproductive Toxicity: No significant evidence from available studies.
Environmental Fate: Hydrolyzes slowly in moist air and water, forming methanol and silanol. Methanol is biodegradable, while silanol reacts further with soil minerals.
Persistence/Degradability: Product breaks down in environment, but hydrolysis byproduct methanol presents a risk to aquatic life in high concentrations.
Bioaccumulative Potential: Low, based on water solubility and breakdown to non-persistent compounds.
Mobility in Soil: Moderate to high, based on partial water solubility of hydrolysis products.
Acute Aquatic Toxicity: Data limited; not expected to be highly toxic to aquatic life but methanol presents moderate toxicity to fish and invertebrates.
Other Hazards: Avoid release into the environment; follow good industrial hygiene practices to limit environmental impact.
Disposal Methods: Dispose of waste and residues in accordance with local, regional, and national regulations. Burn at high temperature in a suitable incinerator or dispose of through licensed chemical waste handler.
Container Disposal: Rinse empty containers thoroughly and offer for recycling, if permitted; otherwise puncture and landfill under appropriate authority.
Special Precautions: Do not dump into sewers, surface water, or soil.
Additional Notes: Dispose as hazardous waste if mixed with other regulated substances.
UN Number: 2810
Shipping Name: Toxic liquid, organic, n.o.s. (contains 2-(3,4-Epoxycyclohexyl)Ethyltrimethoxysilane)
Hazard Class: 6.1 (Toxic substances)
Packing Group: III (minor danger)
Transport Labels: Toxic, Class 6.1
Environmental Hazards: Not a marine pollutant
Special Transport Measures: Protect from physical damage and keep upright. Suitable for ground, sea, and air transport within regulatory guidelines.
Inventory Status: Listed on TSCA (US), EINECS (EU), AICS (Australia), DSL (Canada), ENCS (Japan)
OSHA Hazardous Chemical: Yes
SARA Title III: Not subject to Section 313 reporting
California Proposition 65: Methanol (hydrolysis byproduct) known to cause birth defects, but not present in parent compound
Right to Know (RTK) State Lists: 2-(3,4-Epoxycyclohexyl)Ethyltrimethoxysilane not specifically listed
REACH Restrictions: Registered for industrial use, no special restrictions
WHMIS Classification (Canada): D2B (skin/eye irritant)
Other Regulations: Product subject to chemical safety, hazard communication, and workplace safety standards in many jurisdictions. Safety and handling guidelines must be followed strictly at all times.
