Back in the 1960s, chemists started to get curious about combining silicon chemistry with traditional organic amines. Silanes caught on in labs focusing on adhesives and surface treatments. Through decades, advances in analytical techniques like NMR and GC-MS shaped the way these compounds are understood. Specific derivatives such as 3-(2-Aminoethyl)-N’-[3-(Dimethoxymethylsilyl)Propyl]-1,2-Ethanediamine emerged from research efforts to develop more robust coupling agents for silicate-containing materials and bio-compatible surfaces. Patents filed across the US, Germany, and Japan highlight a growing demand for hybrid molecules that bridge the gap between organic and inorganic substrates. Instrument manufacturers at that time pushed chemistries to fit evolving industrial needs, with each new ingredient aiming for more reliability and performance.
At its core, this compound brings together diamine flexibility and silane reactivity. The two amino groups allow for powerful interactions with a variety of substrates, facilitating crosslinking and modification of both organic and inorganic surfaces. The dimethoxymethylsilyl group serves as a handle for further reactions or anchoring to silicaceous materials. This combination often finds a home in applications requiring both a chemical bond to glass, ceramic, or stone and strong interactions with polymers or resins. The product typically comes as a clear to slightly yellowish liquid, shipped tightly sealed under inert gas to keep moisture at bay.
This product owns a molar mass hovering around 278.44 g/mol, with a boiling point close to 125°C at 5 mmHg. The amine groups give it a strong basic character, making it eager to pick up protons or coordinate to metals. The silane end tends to hydrolyze in contact with water, releasing methanol and forming silanols that readily bond to mineral surfaces. Viscosity sits in the moderate range, so it spreads nicely without dripping off surfaces, and its refractive index offers a quick way for chemists to check purity on the production floor. Stability under ambient conditions remains reliable so long as humidity stays controlled, but in open air, the methoxy groups won’t hesitate to react with atmospheric moisture.
On technical data sheets, the content of active ingredient generally falls above 97%. Specifications tend to include measured content by GC, water content below 0.5%, and typical methanol impurities under 0.2%. Labels warn users about corrosivity to eyes and skin due to the basic amine groups, along with flammability for the methanol released during hydrolysis. Shipping follows UN standards for chemicals, usually coded for substances harmful to health but not under tightest hazardous control.
Manufacturers often use a two-step process: Start with N-(3-chloropropyl)-N’-ethyl-1,2-ethanediamine, then run the alkylation with sodium methoxide and chloromethyl-dimethoxysilane. This approach helps control unwanted side reactions and keeps the methoxy groups in place. High-boiling solvents like toluene or DMSO provide a safe environment for the reaction to proceed smoothly. After synthesis, distillation and careful drying remove by-products and ensure the least possible water content. Storage involves stainless steel or glass-lined tanks under dry nitrogen.
In practical use, this silane-amine crosslinker sees action in a wide range of reactions. Its amine side grabs onto epoxy resins or reacts with isocyanates to form urea linkages. The silyl end handles well in silanization protocols, especially for transforming glass or ceramic surfaces from hydrophilic to hydrophobic or vice versa, or introducing specific functionalities for biomolecule attachment. Once applied, the compound forms robust Si–O–Si networks that resist peeling, moisture, and chemical attack. Researchers have also modified this backbone to tune functionality, swapping out alkoxy groups or stretching the organic linkers for custom fit in diverse polymer matrices.
Trade and lab supply catalogs identify this product under names such as "Bis(2-aminoethyl)-N-[3-(dimethoxymethylsilyl)propyl]amine," and in some contexts, it appears as "Aminoethyl-silane diamine." Researchers sometimes abbreviate to AEAPS for shorthand in publications, and certain vendors have their own naming conventions. Awareness of alternate names avoids confusion when sourcing or comparing technical literature.
Staying safe with this compound means handling inside properly vented hoods, donning gloves and goggles, and keeping emergency eyewash nearby. The methoxy groups love to hydrolyze, creating methanol, which brings its own toxic and flammability hazards. I once watched a few milliliters hydrolyze on a bench, and the odor alone signaled the need for sharp chemical awareness. Labs should keep all waste liquids separate and neutralize with acid before disposal. In the industrial space, best practices call for explosion-proof electricals in storage areas and rigid protocols for moisture control.
This aminated silane made its biggest impact in adhesion promoters for composite materials, especially where glass fibers meet polyamide and epoxy resins. In coatings and paints, its dual function helps bind pigments and protectural surfaces. The medical device field found a use for this molecule when modifying glass for biosensor arrays or drug delivery microchips, since it forms stable and customizable layers. Silane chemistry like this keeps popping up in effluent water treatment as a crosslinker for advanced polymers, helping trap and extract heavy metals. I watched a pilot plant test with modified membranes hold tight to lead and cadmium, a trick that would be tough without this type of chemistry.
Innovation keeps stretching the reach of silane-diamine hybrids, as scientists seek new ways to tether biomolecules, engineer better hydrogels, or push anti-fouling coatings. Research funding in the EU and Asia targets environmental protection—think air filters, catalytic surfaces, or smart membranes. Biomedical researchers in university labs have explored this compound for targeted drug loading onto silica nanoparticles, using the twinned amine groups for further derivatization. Developers keep adjusting molecular structure for enhanced selectivity or reactivity, and computer-aided modeling helps predict new behaviors before they hit the bench.
Hazard studies show the parent compound irritates eyes and skin, common for amine-containing chemicals, with methanol release from hydrolysis being a prime concern. Inhalation exposure raises acute toxicity for unprotected operators. Chronic exposure studies need more work, but standard procedures recommend robust air monitoring and medical surveillance. Environmental reviews show slow-to-moderate biodegradation, so treating process streams before discharge becomes critical for compliance with wastewater regulations. Animal data from related silanes suggest low carcinogenicity, yet the lack of long-term studies means keeping controls and PPE in steady use.
Looking forward, demand for specialty silane agents like this one will only rise with the trend toward advanced, multi-material devices and green infrastructure. Global infrastructure upgrades will rely on high-performance adhesives and coatings to extend lifespans with less maintenance. The medical technology sector eyes this compound for new biointerfaces: implant coatings, smart bandages, or molecular tagging for diagnostics. With sustainability in mind, chemists keep testing renewable feedstocks and lower-energy syntheses, aiming for greener production and smarter disposal options. At the same time, digital manufacturing—3D printing for dental or custom electronics—stands to benefit from the flexible reactivity and bonding profiles brought by this kind of silane-amine hybrid, suggesting its impact is just starting to unfold.
Start talking to anyone in materials science or advanced manufacturing, and pretty soon you’ll hear about organosilanes. 3-(2-Aminoethyl)-N’-[3-(Dimethoxymethylsily) Propyl]-1,2-Ethanediamine, despite the long-winded name, fits right into that world. This molecule brings together two things: silicon, found in those “dimethoxymethylsilyl” arms, and a bunch of nitrogen-rich portions. So why do people care?
Take adhesives and coatings. Most things we encounter in daily life don’t stick together on their own. Metals and plastics are notorious for fighting off glue and paint. Chemists figured out long ago that a bridge was needed between two worlds: the hard, inorganic stuff like glass or metal, and the soft, squishy world of organic coatings, paints, or even medical adhesives. This molecule steps in as that bridge. One end latches firmly onto things like glass, guiding a layer of paint or an epoxy resin to hold tight. The other end is happier with things like plastics or amino-functional polymers, so everything stays locked in place, even when stress tries to pull things apart.
Anyone who’s struggled with the peeling paint at home, or who’s ever thanked the heavens for a reliable waterproof seal in their bathroom, has felt the effect of workhorse compounds like this one. Product reliability gets better, coatings last longer, and failure rates drop. In automotive assembly, electronic packaging, and even in hospitals, this molecule helps materials stand up to moisture, heat, and chemical attack. Imagine electronics failing because a drop of water sneaked in — now picture a mastering of that weak spot thanks to treatment with these functional silanes.
On a more personal note, I used to wonder why the caulking around my bathroom tiles lasted years longer than the cheap stuff. The answer turned out to be smarter surface chemistry. Adhesive companies put these silanes in their products, making them bond more powerfully to ceramic and glass. These bonds help fight off mold and mildew and keep everything where it belongs, without cracking or peeling.
It’s easy for chemical manufacturers to talk up performance, but there’s a responsibility that comes with wide use. Materials that sit between metals and plastics may end up in drinking water systems or places where people and pets have regular contact. Safety data must be publicly available, and long-term health impacts demand close study. The best manufacturers share testing results and encourage outside reviews of health, performance, and environmental effects. End users gain confidence when these steps aren't skipped, and that matters both in industry and at home.
Looking deeper into published studies, most point to low acute toxicity and minimal environmental risks when this molecule shows up in cured (hardened) materials. Still, anyone handling uncured products is wise to use proper ventilation and gloves.
The big push in recent years focuses on sustainability. Chemists get creative with new silane molecules that do their jobs with even less risk. Water-based formulations, improved recycling, and less-volatile byproducts matter not just for compliance, but for creating more responsible products.
For people working with these materials, ongoing education matters. Staying up to date about formulations and new research leads to smarter choices and safer workplaces. For buyers and builders, choosing adhesives or coatings from transparent suppliers helps everyone avoid the headaches of early failure or worrying surprises down the road.
Safety slips through the cracks every time folks overlook the basics of storage and handling. Working in the warehouse, I've seen how skipping small steps can turn a regular day into a headache you can’t shake off. For any product—chemical, food, pharmaceutical—the rules come down to the same purpose: protect people and keep the product in good shape. If someone in the chain drops the ball on this, everything from safety fines to ruined shipments follows pretty fast.
A lot of instructions talk about temperature ranges like they're a nice suggestion. Too warm, certain goods lose their punch—think vitamins, perishable foods, even adhesives. Too cold or too damp, and you’re looking at clumps, spoiled stock, or containers cracking from within. Data loggers and simple thermometers make a world of difference, eliminating the guesswork. In summer or in poorly insulated spaces, air conditioning and climate controls aren't luxuries; they save product and, in some cases, people from health risks. A New England food co-op I worked with upgraded their walk-in cooler, trimming spoilage rates by over 20% within months.
Stacking boxes right up to the ceiling looks efficient until heavy loads start tumbling. OSHA reports tie back injuries and workplace accidents to poor material handling more often than sloppy paperwork. The repeat offenders: overloading shelves, putting heavy items at shoulder height, or skipping the pallet jack because it's a few steps away. Pallets and bins made of the right material—metal for chemicals, food-grade plastic for perishables—make a difference. Strong storage racks, clear lane markings, and routine walkthroughs do more than any sign on the wall.
Confusion sparks chaos. Color-coded labels and proper signage cut down on expensive mix-ups. One mix-up in the medical sector made headlines after similar-looking packages went to the wrong units—nobody hurt, but trust took a hit. Regular training—hands-on, not just slides—prepares folks to handle spills, breaks, even emergencies. Giving everyone ten minutes to refresh on handling protocols each month reduces mistakes and puts less pressure on supervisors.
Gloves, goggles, and the right masks don’t just tick a box for compliance—they keep burns, rashes, and lasting harm off the table. Chemical burns and inhalation injuries send thousands to the hospital every year, according to CDC figures. Readily available eyewash stations, spill kits, and clear protocols for disposal let everyone relax and focus on getting the job done. Drills help, too. At a previous job, our response time to a small warehouse spill dropped by half after routine practice.
Inventory software and RFID scanners save piles of paperwork and hours of labor, stopping small mix-ups from turning into major losses. Real-time tracking alerts staff about stock at risk from temperature swings or rough handling. Many adopters see shrinkage cut by as much as a third in the first year. Sharing data across locations helps managers recognize problems and put fixes in place before something gets out of hand.
Habits built around clear guidelines, up-to-date tools, and good training turn even the busiest loading dock or storage room into a safer, more productive space. All these pieces—right down to how a label gets read—protect people, property, and the reputation of everyone in the supply chain. The small steps aren’t always glamorous, but they keep the wheels moving in the right direction.
In a typical work environment, whether it’s a bustling construction site or a factory floor filled with heavy machinery, ignoring basic safety not only puts lives in danger, it can stop production and drain resources fast. I’ve seen what even one shortcut can cost. Once, a co-worker decided to skip his earplugs “just for a minute.” The result? Ongoing hearing issues. It taught everyone around us how quickly routine tasks turn risky when respect for precautions slips.
It’s easy to spot a hazard in hindsight. Loose wires, unguarded blades, or chemicals stored carelessly seem obvious now, but during a packed shift, people focus on deadlines. That’s why these hazards pop up more often than we admit. I remember working night shifts, using old extension cords to power extra lights. No one planned for a short circuit, but one happened anyway, shutting down half the floor and sending a coworker to first aid for burns. Routine gear didn’t cut it; better planning would have meant safer cords and fewer risks.
Some dangers repeat across many jobs. Electrical fires don’t just damage property; they risk lives, and many start because tools or outlets get overloaded. Heavy objects on high shelving threaten everyone below when racks get bumped or older supports fail. Dust, fumes, or chemical spills bring slow long-term problems, like lung trouble or skin rashes, sometimes diagnosed only years later. I’ve seen shops where everyone coughs in winter because of poor ventilation—often, no one fixed ancient fans or windows that refused to open.
Organized gear makes a huge difference. Well-kept fire extinguishers and labeled exits give people a real chance to get clear of danger. Hearing protection, gloves, and eye shields sound basic, but they only work if everyone trusts their gear and managers replace old safety stock. Training isn’t a one-off event—people forget steps when they change roles or new machines arrive. Real protection happens when everyone feels some responsibility, not just for rules, but for watching out for each other.
The costs of ignoring safety add up: lost workdays, medical bills, and burned-out workers often come straight from lapses that seemed small at first. It’s cheaper—and smarter—to fix even minor safety issues before they grow. Businesses that put effort into clear signage, restocking supplies, and routine walk-throughs actually improve morale too; nobody likes working where they feel expendable.
Some answers are simple, like fixing leaks right away, running tool checks every shift, or keeping walkways clear of clutter. Open conversations do more than memos—sharing stories of close calls or “almost accidents” goes further than statistics. Technology won’t solve everything, but sensor alarms, auto-shutoff switches, and digital maintenance logs help keep pace with new risks. In shops I’ve worked in, team members who feel heard speak up sooner, before near-misses turn into real disasters. That kind of culture doesn’t come from the safety office—it grows from real experiences, earned one lesson at a time.
Plenty of folks would rather look away than deal with a bottle of leftover chemicals sitting on a garage shelf or a lab bench. I’ve seen more than a few people dump something down the drain thinking, "It’ll be fine, the water plant will handle it." That attitude creates real problems for everyone. Not every compound stays harmless in the pipes—some bind with metals, others create hazardous byproducts. The pipes underneath our feet and the streams that run through our backyards don’t need any extra chemistry. I learned this years ago, watching a classmate pour a nickel solution into a campus sink. That same nickel eventually ended up on an environmental report by our utility company. We're all more connected than we think.
A single step in the right direction does more than wishful thinking ever could. Fact is, almost every town offers hazardous waste collection days or drop-off centers. Not fancy, but it works. When in doubt, ask your local waste department for advice. No shame in admitting you don’t have the answer—the harm comes from pretending a problem doesn’t exist. Every year, household collection days keep lead, mercury, solvents, and mysterious powders out of landfill and local rivers. These community projects do more for public health than most folks realize.
Manufacturers print handling instructions on every bottle or drum for a reason. Those warnings and symbols aren't just legal fluff. Material Safety Data Sheets (now called SDS) are a gold mine for anyone facing an unfamiliar name or formula. Years ago, I worked with a solution that looked like plain water—later I learned it could eat through copper pipes in a matter of hours. A quick read of the SDS kept me from making a costly mistake. Learning to translate hazard symbols is a life skill: corrosion, flammability, reactivity—each clue shapes your next move.
Local and national rules make chemical disposal more than a suggestion. In the United States, laws like the Resource Conservation and Recovery Act (RCRA) outline what has to go to special facilities, what can be neutralized, and what should never touch soil or water. Fines for ignoring these rules aren’t light. I once saw a school chemistry lab fined for pouring diluted acids down the drain. Someone has to pay for cleanup, and usually, it’s us—the taxpayers—when corners get cut. The law expects adults to respect their environment just as much as any company.
Asking questions and keeping up with good disposal habits means fewer headaches for everyone. Buying only what you'll use, labeling leftovers, keeping chemicals in the right containers, and checking for leaks keeps surprises to a minimum. These habits end up saving money, time, and trouble. In a world where microplastics and heavy metals are showing up even in remote corners, every bit of effort counts. That old bottle in the garage doesn’t need to become someone else’s problem. Informed choices make all the difference. Safety starts in our own homes and workspaces, long before the community sweeper rolls by.
In the world of chemistry, people often overlook what's written on the packaging. They pick up a container, see a date or a temperature range, and shrug, thinking it’s just a suggestion. The truth is, those details didn’t come out of nowhere. Scientists run stability tests for months — sometimes years — to figure out how long a chemical can stay useful without turning into something less predictable or, in some cases, even dangerous.
Think about working in a school lab. I remember opening a container of glacial acetic acid only to smell strong, sharp vinegar that knocked me back. That smell showed the chemical had gone bad. If I had paid attention to shelf life, I would've caught the clue. Poor storage can lead to more than bad odors — it can mean shelf-stable products suddenly don’t behave as planned, or worse, become hazardous.
Every chemical comes with its personality. Some stay tough at room temperature, others prefer the fridge, and a few need the deep freeze. Take hydrogen peroxide — even a mild temperature rise gradually breaks it down into water and oxygen. So, a cool room helps it last longer and actually do its job. Jack up the heat, and that clear bottle quickly becomes mostly water.
Practically speaking, most organics and inorganics hold steady between 15°C to 25°C. Once things get warmer or colder, their molecules start acting differently. Some react with air, others absorb water straight from the atmosphere, or settle into solids if left somewhere too cold. I’ve seen sodium hydroxide pellets turn into a brick because someone left the jar open and forgot the desiccant. Just a little moisture in the air, and you get a mess.
Running a lab or even a paint workshop, mistakes often start with the basics. Out-of-date chemicals ruin experiments, spoil paint mixes, or gum up cleaning processes. Relying on expired material leads to wasted time, money, and sometimes dangerous byproducts. Over the years, I’ve learned to keep reliable inventory — a habit that saves headaches for everyone down the line.
Misreading storage instructions goes beyond ruined results. Sometimes it invites catastrophic failures: mixes that explode, materials that catch fire, or fumes that send people to the hospital. Regulatory guidelines and safety data sheets keep it simple — store at a certain temperature, use within a set time, seal tightly, and, where needed, use desiccants or inert gas overlays.
Every facility should design a quick system for reviewing shelf life and storage. A digital log or a good old notebook with “Date In, Date Out” next to every chemical works wonders. Posting reminders for temperature checks near chemical storage spaces keeps things safe and organized. Encourage everyone — from seasoned chemists to new lab assistants — to follow checklists and leave no questions about what sits on the shelf.
No one can afford to take shortcuts with things that react, corrode, or fume. Small efforts in temperature control and date-tracking pay off every day. Keeping chemicals at their best isn’t just about following rules — it’s about protecting work, health, and, sometimes, lives.
| Names | |
| Preferred IUPAC name | N¹-[3-(Dimethoxymethylsilyl)propyl]ethane-1,2-diamine-3-ethylamine |
| Other names |
N-(2-Aminoethyl)-3-(dimethoxymethylsilyl)propyl-1,2-ethanediamine N-[3-(Dimethoxymethylsilyl)propyl]ethylenediamine 3-(2-Aminoethylamino)propylmethyldimethoxysilane |
| Pronunciation | /θri æmˌiːnoʊˈɛθəl ɛn prɑːpɪl ˈdɪməˌθɒksiˌˈmɛθəlˌsaɪli ˈprəʊpɪl ˈiːθəˌndiːəˌmiːn/ |
| Identifiers | |
| CAS Number | 15375-84-5 |
| Beilstein Reference | 2220963 |
| ChEBI | CHEBI:149403 |
| ChEMBL | CHEMBL4209093 |
| ChemSpider | 4087158 |
| DrugBank | DB12630 |
| ECHA InfoCard | ECHA InfoCard: 100.254.465 |
| EC Number | 805-780-9 |
| Gmelin Reference | 863315 |
| KEGG | C09718 |
| MeSH | D02.241.223.211.438 |
| PubChem CID | 26034708 |
| RTECS number | NJ6462400 |
| UNII | GXU5X0Q953 |
| UN number | UN3334 |
| Properties | |
| Chemical formula | C12H31N3O2Si |
| Molar mass | 365.61 g/mol |
| Appearance | Colorless to light yellow transparent liquid |
| Odor | Amine-like |
| Density | 0.990 g/mL at 25 °C |
| Solubility in water | soluble |
| log P | -1.18 |
| Acidity (pKa) | 10.1 |
| Basicity (pKb) | 5.8 |
| Refractive index (nD) | 1.4790 |
| Viscosity | 160 cP |
| Dipole moment | 3.4527 Debye |
| Pharmacology | |
| ATC code | This compound does not have an ATC code. |
| Hazards | |
| Main hazards | Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Harmful to aquatic life with long lasting effects. |
| GHS labelling | GHS02, GHS05, GHS07 |
| Pictograms | GHS07, GHS05 |
| Signal word | Warning |
| Hazard statements | H315, H319, H412 |
| Precautionary statements | Precautionary statements: P261, P264, P271, P272, P273, P280, P302+P352, P305+P351+P338, P333+P313, P337+P313, P362+P364, P403+P233, P405, P501 |
| NFPA 704 (fire diamond) | 1-3-0 |
| LD50 (median dose) | LD50 (median dose): >5000 mg/kg (Rat) |
| NIOSH | Not listed |
| PEL (Permissible) | Not Established |
| REL (Recommended) | 200-500 mg/L |
| Related compounds | |
| Related compounds |
N-(2-Aminoethyl)-3-aminopropyltrimethoxysilane 3-(2-Aminoethylamino)propyltrimethoxysilane N-(3-Trimethoxysilylpropyl)ethylenediamine Bis(3-aminopropyl)amine N-(2-Aminoethyl)-3-aminopropyltriethoxysilane |
