Product Name: 3-Aminopropylmethyldimethoxysilane
Chemical Formula: C6H17NO2Si
Synonyms: N-(3-Trimethoxysilylpropyl)methanamine, A-1521
CAS Number: 3663-44-3
Recommended Use: Coupling agent in adhesives, sealants, coatings, and chemical synthesis
Supplier Details: Supplier name, address, phone number, and emergency contact number included on container label
Emergency Phone Number: Check chemical supplier's emergency contact for regional information
Classification: Flammable liquid (Category 3), Skin corrosion/irritation (Category 2), Eye damage/irritation (Category 1), Sensitization – Skin (Category 1B), Acute toxicity – Oral/Inhalation (Category 4), Aquatic hazard – Chronic (Category 3)
Signal Word: Danger
Hazard Statements: Causes serious eye damage, causes skin irritation, may cause allergic skin reaction, harmful if swallowed or inhaled, flammable liquid and vapor, harmful to aquatic life with long lasting effects
Pictograms: Flame, exclamation mark, corrosion, environment
Precautionary Statements: Use explosion-proof electrical equipment, wear protective gloves, avoid release to the environment, wash thoroughly after handling, keep container tightly closed, keep away from ignition sources, ground/bond container and receiving equipment
Chemical Name: 3-Aminopropylmethyldimethoxysilane
CAS Number: 3663-44-3
Concentration: 97%–100% by weight
Impurities: Methanol (by-product, trace amounts possible), other organosilane residues in trace quantities
Additives: No commercial stabilizers or additives specified for this material
Inhalation: Immediately remove person to fresh air, keep at rest and monitor breathing, administer oxygen if necessary, seek medical attention for respiratory symptoms
Skin Contact: Remove contaminated clothing, flush skin with plenty of water for at least 15 minutes, wash with mild soap, seek medical help if irritation or rash develops
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, get medical advice immediately
Ingestion: Rinse mouth, do not induce vomiting, keep individual calm, contact poison control or physician right away
Notes to Physician: Treat symptomatically and monitor for severe eye or skin damage, supportive care as indicated for chemical burns and respiratory irritation
Suitable Extinguishing Media: Dry chemical, CO2, foam, alcohol-resistant foam, water spray (do not use direct water stream)
Specific Hazards: Flammable liquid and vapor, may release toxic fumes of carbon oxides, nitrogen oxides, silicon oxides, and methanol on combustion
Special Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus required
Advice for Firefighters: Stay upwind, use water spray to cool exposed containers, prevent run-off from entering drains and waterways
Fire Hazard Statements: Vapors can form explosive mixtures with air, containers may explode when heated due to pressure build-up
Personal Precautions: Evacuate unnecessary personnel, ventilate area, use appropriate personal protective equipment including gloves, goggles, and respiratory protection
Environmental Precautions: Prevent from entering sewers, waterways, and soil, notify authorities if large spills cannot be contained
Methods for Cleanup: Eliminate ignition sources, absorb with inert material such as sand or vermiculite, collect spilled material in container for disposal, clean contaminated surface thoroughly
Decontamination: Wash area with plenty of water, ventilate area, dispose of waste according to local regulations
Handling: Use only in well-ventilated areas, ground and bond containers during transfer, avoid breathing vapor or mist, prevent skin and eye contact, keep away from heat, sparks, and open flame
Storage Conditions: Store in tightly closed original container in dry, cool, and well-ventilated place away from incompatible substances such as strong acids, oxidizing agents, and moisture
Special Storage Requirements: Keep away from sources of ignition, store out of direct sunlight, use non-sparking tools and equipment, store away from food and beverages, keep container clearly labeled and sealed
Engineering Controls: Enclose process if possible, use local exhaust ventilation, keep air concentrations below occupational exposure limits
Personal Protection–Eyes: Chemical safety goggles or face shield
Personal Protection–Skin: Nitrile or neoprene gloves, long-sleeved clothing, protective boots
Personal Protection–Inhalation: Where vapor or mist is present, use NIOSH-approved respirator
Occupational Exposure Limits: No established ACGIH or OSHA threshold limit values for this chemical; control based on presence of methanol and other volatiles
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke in chemical areas, remove and wash contaminated clothing before reuse
Appearance: Transparent colorless to pale yellow liquid
Odor: Amino, ammonia-like
Odor Threshold: Not established
pH: 10.5–11.5 (aqueous solution)
Melting Point/Freezing Point: -65°C (estimated)
Initial Boiling Point and Range: About 205°C
Flash Point: 75°C (Closed cup)
Evaporation Rate: Not determined
Flammability (solid, gas): Not applicable
Upper/Lower Flammability or Explosive Limits: Upper: 13%, Lower: 1.0% (methanol component)
Vapor Pressure: 0.4 mmHg @ 20°C
Vapor Density: >1 (air = 1)
Relative Density: 0.96-1.01 (water = 1)
Solubility: Hydrolyzes in water, miscible with many organic solvents
Partition coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not established
Decomposition Temperature: Not established
Viscosity: 1.2–1.6 mPa·s at 25°C
Chemical Stability: Stable under recommended storage conditions, hydrolyzes in water producing methanol
Reactivity: Reacts with water, acids, and alcohols, generates heat and methanol
Conditions to Avoid: Moisture, uncontrolled exposure to air, heat, spark, flame, incompatible chemicals
Incompatible Materials: Strong oxidizers, acids, alkalis, water (hydrolysis produces methanol), strong acids promote polymerization
Hazardous Decomposition Products: Methanol, silicon oxides, carbon oxides, nitrogen oxides, ammonia under fire conditions
Polymerization: No hazardous polymerization under normal handling, risk increases in acidic environments
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Effects: Causes severe irritation and burns to eyes, reversible to severe damage to skin and mucous membranes, respiratory tract irritation
Inhalation Toxicity: May cause coughing, sore throat, dizziness, headache, possible nervous system effects from methanol
Ingestion Toxicity: Harmful, may cause nausea, vomiting, abdominal pain, and central nervous system effects
Dermal Toxicity: Prolonged contact leads to irritation and possible sensitization
Chronic Effects: Skin sensitization, allergic reactions after repeat exposure, repeated inhalation may affect liver and kidneys
Carcinogenicity: No data from IARC, NTP, or OSHA on carcinogenicity for this compound
Reproductive Toxicity: Methanol, a by-product, is known to cause birth defects
LD50/LC50 (estimated): Oral (rat): ~1,700 mg/kg, Dermal (rabbit): >2,000 mg/kg
Aquatic Toxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Hydrolyzes to methanol and silanol under environmental conditions, some persistence in soil possible due to interaction with minerals
Bioaccumulative Potential: Not expected to bioaccumulate significantly
Mobility in Soil: High mobility, hydrolyzed products migrate with groundwater
Other Adverse Effects: Methanol component has documented harmful effects on aquatic life at relatively low concentrations, local spills can disrupt biological wastewater treatment processes
Waste Treatment Methods: Incineration in authorized chemical waste facility recommended, comply with federal, state, and local regulations
Disposal of Contaminated Packaging: Rinse thoroughly and dispose as hazardous waste, do not reuse containers, ensure proper labeling
Special Precautions: Avoid release to environment, prevent spillage from reaching surface waters or drains
UN Number: UN 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (3-Aminopropylmethyldimethoxysilane)
Transport Hazard Class: 3 (Flammable Liquids)
Packing Group: III
Environmental Hazards: Not classified as marine pollutant, precaution for aquatic toxicity
Special Transport Precautions: Use approved containers, segregate from oxidizers and foodstuffs, ensure containers upright and sealed
OSHA: Classified hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200)
TSCA: Listed on Toxic Substances Control Act Inventory
SARA Title III: Not classified as extremely hazardous, no specific reportable thresholds for this compound; methanol may trigger reporting requirements depending on volume
REACH/CLP (EU): Requires registration in EU, labeled as dangerous for health and environment
DSL/NDSL (Canada): Listed
California Prop 65: Methanol listed as reproductive toxin
Other Regulations: Follow all national, state, and local regulations regarding labeling, transport, workplace exposure, and environmental protection
