Product Name: 3-Aminopropyltrimethoxysilane
Chemical Formula: C6H17NO3Si
Synonyms: APTMS, Silane, 3-aminopropyltrimethoxy-
CAS No.: 13822-56-5
Recommended Use: Adhesion promoter, surface modifier for glass, metals, plastics, composite materials
Manufacturer/Supplier: Available from multiple global suppliers; technical customer support provided by specialty chemical distributors
Emergency Phone Number: Refer to supplier's 24-hour line or local poison control
Address: Refer to container label or shipping papers for supplier location
Classification: Flammable liquid (Category 3); Skin corrosion/irritation (Category 2); Serious eye damage (Category 1); Acute toxicity, oral (Category 4)
Signal Word: Danger
Hazard Statements: Causes serious eye damage; Causes skin irritation; Harmful if swallowed; Flammable liquid and vapor
Pictograms: Flame, Corrosive, Exclamation mark
Precautionary Statements: Avoid breathing vapors; Wash skin thoroughly after handling; Keep away from sources of ignition; Use eye protection; Keep container tightly closed; In case of accident, seek medical attention promptly
Chemical Name: 3-Aminopropyltrimethoxysilane
Concentration: >98%
Impurities: Methanol may be generated during hydrolysis; few trace byproducts below 1%
CAS Number: 13822-56-5
Molecular Weight: 179.29 g/mol
Inhalation: Move affected person to fresh air immediately; rest and stay warm; seek medical attention for persistent symptoms such as headache, nausea, or respiratory discomfort
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; consult a doctor if irritation develops or persists
Eye Contact: Rinse opened eye with plenty of water for at least 15 minutes; remove contact lenses if possible; seek ophthalmologist care due to risk of severe damage
Ingestion: Rinse mouth, drink a small amount of water; do not force vomiting; get medical help right away if feeling unwell; provide product label or SDS to emergency responders
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, CO2, water spray
Unsuitable Media: Direct water jet may spread the fire
Specific Hazards: Combustion creates toxic fumes; methanol may form upon burning or hydrolysis, adding explosive hazard
Protective Equipment: Self-contained breathing apparatus, full protective gear
Special Procedures: Cool containers with water spray; keep upwind; evacuate area if high vapor concentrations
Personal Protection: Wear protective suit, gloves, and goggles; avoid breathing vapor; ventilate area
Environmental Precautions: Prevent product from entering drains, soil, or surface water; report release to local authorities as required
Containment: Dike spilled material; use inert absorbents such as sand or earth
Clean-Up: Collect with non-sparking tools into sealable containers for proper disposal
Handling: Work in well-ventilated areas away from flames or sparks; avoid skin, eye, and clothing contact; use equipment rated for flammable liquids
Storage Conditions: Store in original, tightly sealed containers; keep in a dry, cool place away from moisture, acids, oxidizers; protect from sunlight; segregate from food and feed
Incompatibility: Water and moisture accelerate hydrolysis, forming corrosive and flammable methanol; avoid acids and strong oxidizing agents
Engineering Controls: Local exhaust ventilation or process enclosure to limit vapors
Eye/Face Protection: Chemical splash goggles, full-face shield if risk of splashing
Hand Protection: Nitrile rubber or neoprene gloves; polyvinyl alcohol not recommended
Body Protection: Chemical-resistant clothing such as lab coat or apron
Respiratory Protection: Use organic vapor respirator if ventilation insufficient
Hygiene Measures: Routine handwashing after exposure; remove contaminated clothing immediately and launder before reuse
Appearance: Clear, colorless to pale yellow liquid
Odor: Amine-like, faint
Odor Threshold: Not available
pH: 10 to 12 (5% solution)
Melting Point: Below -50°C
Boiling Point: 194–196°C @ 101 kPa
Flash Point: 85°C (closed cup)
Evaporation Rate: Slower than butyl acetate
Flammability: Flammable liquid
Vapor Pressure: 0.2 mmHg @ 25°C
Vapor Density: 6.2 (air = 1)
Relative Density: 1.03 (water = 1) @ 25°C
Solubility: Reacts/exotherms with water; soluble in alcohols, ketones
Partition Coefficient (log Pow): -1.2 (estimated)
Auto-Ignition Temp: 290°C
Decomposition Temp: Not determined
Viscosity: 2–3 mPa·s @ 25°C
Chemical Stability: Stable under recommended storage; gradually hydrolyzes upon moisture contact forming methanol and silanols
Reactivity: Vigorously reacts with water, acids
Potential Hazards: Vapor forms explosive mixtures with air; hydrolysis releases flammable methanol
Incompatible Materials: Acidic, strongly oxidative, or water-rich materials; container materials not rated for amines or alcohols
Decomposition Products: Methanol, ammonia, organic siloxanes, carbon oxides
Acute Toxicity: LD50 (oral, rat): 2295 mg/kg; LD50 (dermal, rabbit): 4076 mg/kg
Skin Corrosion/Irritation: Causes moderate to severe irritation, burns after prolonged contact
Eye Damage/Irritation: Causes irreversible eye injury
Respiratory Sensitization: No clear data, but vapor may irritate airways
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Mutagenicity: No data supporting mutagenic effects; methanol metabolite is toxic
Target Organ Effects: May damage eyes, skin, nervous system (from methanol exposure); ingestion risk for kidney and liver
Chronic Exposure: Prolonged inhalation may cause central nervous system effects similar to methanol poisoning, such as headache, dizziness, and blurred vision
Ecotoxicity: No data for the pure compound, but expected to be harmful to aquatic organisms due to pH shifts and solvent effects; rapidly hydrolyzes
Aquatic Toxicity: LC50 (96h, fish): >100 mg/L; EC50 (48h, Daphnia): 331 mg/L (hydrolysis product)
Persistence/Degradability: Hydrolyzes in water forming organosilanols and methanol; ultimate biodegradation expected after hydrolysis
Bioaccumulative Potential: Low due to high solubility and rapid breakdown
Mobility in Soil: Moves readily in moist environments, but hydrolysis limits hazard duration
Other Adverse Effects: Release to waterways threatens aquatic pH and oxygen balance due to amine content
Waste Disposal: Dispose of in accordance with local, regional, and national regulations; suitable for incineration with flammable organics in licensed facilities
Container Handling: Triple rinse before disposal or recycling; puncture or destroy to prevent reuse
Precautions: Do not allow material or rinsing to contaminate soil, groundwater, or sewers; prevent release of methanol byproducts into the environment
Contaminated Packaging: Handle as hazardous waste unless decontaminated
UN Number: UN 1993
Shipping Name: Flammable Liquid, N.O.S. (contains 3-Aminopropyltrimethoxysilane)
Class: 3 (Flammable liquid)
Packing Group: III
Label: Flammable Liquid Symbol
Special Precautions: Keep containers upright; segregate from foodstuffs and incompatible materials; secure loads against movement; document emergencies for carrier
OSHA: Classified as hazardous; workplace exposure limits for methanol byproduct apply
TSCA: Listed on the Toxic Substances Control Act inventory
DSL/NDSL (Canada): Listed/registered
EU REACH: Compliant as per supplier’s declaration; hazard labeling per CLP Regulation
SARA Title III: Not regulated for reportable quantities, but methanol generated is a listed substance
Right-to-Know: Ingredients listed on state inventories including California Proposition 65 (methanol developmental toxicity)
Other Regulations: Follow all applicable worker safety, labeling, and environmental release rules; employer must inform workers of dangers and safe use
