Product Name: 3-Chloroisopropyoxysilane
Synonyms: 1-Chloro-3-(isopropoxy)silane, 3-chloro-1-(propan-2-yloxy)silane
Chemical Family: Organochlorosilane
CAS Number: 13154-25-1
Manufacturer: Contact supplier or manufacturer for up-to-date company details
Recommended Use: Silane coupling agent, chemical intermediates
Emergency Phone Number: Refer to supplier-specific emergency contacts
Classification: Flammable liquid, acute toxicity (oral and inhalation), skin corrosion, serious eye damage, specific target organ toxicity (single exposure)
GHS Label Elements: Danger
Hazard Statements: Causes severe skin burns and eye damage. Harmful if inhaled or swallowed. Flammable liquid and vapor. May cause respiratory irritation.
Precautionary Statements: Avoid breathing mist, vapors, or spray. Keep away from open flames, heat, and sparks. Wear protective gloves, clothing, and eye/face protection. Use only outdoors or in well-ventilated area. Wash skin thoroughly after handling.
Symptoms of Exposure: Burning sensation, coughing, headache, drowsiness, nausea, skin redness, watery eyes
Environmental Hazards: Harmful to aquatic life. Avoid release into environment.
Chemical Name: 3-Chloroisopropyoxysilane
CAS Number: 13154-25-1
Concentration: ≥98%
Impurities: May contain trace amounts of related chlorosilanes, isopropanol, or hydrochloric acid
Molecular Formula: C6H13ClOSi
Molecular Weight: 168.71 g/mol
Inhalation: Remove person to fresh air. Provide oxygen if breathing is difficult. Seek medical attention if symptoms persist or worsen.
Skin Contact: Remove contaminated clothing. Flush affected area with plenty of water for at least 15 minutes. Get medical help for persistent irritation or burns.
Eye Contact: Rinse eyes with water for at least 15 minutes, lifting eyelids. Remove contact lenses if present and easy to do. Seek immediate medical attention.
Ingestion: Do not induce vomiting. Rinse mouth with water. Never give anything by mouth to an unconscious person. Call a poison center or physician at once.
Most Important Symptoms/Effects: Severe irritation, chemical burns, respiratory distress, gastrointestinal discomfort
Note to Physicians: Treat symptomatically. Monitor for delayed pulmonary edema after inhalation. Pay close attention to airway management due to potential caustic injuries.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam. Use water spray to cool containers.
Unsuitable Extinguishing Media: Do not use water jet directly, as contact with water may generate corrosive gases.
Specific Hazards: Vapors may form explosive mixtures with air. Container rupture under intense heat possible. Decomposition products release hydrogen chloride, silicon oxides, carbon oxides.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective suit. Approach fire from upwind side.
Special Procedures: Move containers away from fire if safe. Prevent firewater runoff from entering drains or water systems.
Personal Precautions: Evacuate area. Ventilate affected space. Use proper respiratory protection.
Protective Equipment: Chemical splash goggles, appropriate gloves, flame-resistant clothing, respiratory gear when airborne concentrations are high.
Emergency Procedures: Keep unprotected persons away from spill site. Remove ignition sources.
Spill Containment: Contain spill with inert absorbent (e.g. vermiculite, sand). Do not allow into sewers or water courses.
Cleanup Methods: Scoop absorbed material into labeled, sealable drums. Wash down area with water after removal. Dispose according to local, regional, national regulations.
Handling: Use only with adequate ventilation. Avoid inhaling vapors or mist. Prevent skin and eye contact. Take measures to prevent static discharge. Keep containers tightly closed when not in use.
Storage: Store in flammable liquid cabinet or approved facility. Keep away from direct sunlight, incompatible chemicals (acids, bases, moisture, oxidizers). Recommended storage temperature range: 2°C to 8°C. Use original packaging or tightly sealed containers made of compatible material (e.g. glass, certain plastics).
Special Advice: Label area and containers clearly. Separate from food and drink.
Exposure Limits: No established occupational exposure limits for 3-chloroisopropyoxysilane. Use with caution.
Engineering Controls: Local exhaust ventilation or fume hoods recommended. Eye wash stations and safety showers in proximity.
Personal Protection: Nitrile or neoprene gloves, chemical safety goggles, face shield, lab coat or apron, flame-resistant clothing in settings with fire risks. Use approved respirator (e.g. organic vapor cartridge) for high vapor concentrations or accidental release.
Hygiene Measures: Wash hands, face, and exposed skin after handling. Remove contaminated clothing and launder before reuse.
Appearance: Colorless to pale yellow liquid
Odor: Acrid, irritating
Odor Threshold: Low; specific value not determined
pH: Not applicable (reacts with water)
Melting Point/Freezing Point: Approx. -75°C
Boiling Point: 140–160°C
Flash Point: 45°C (closed cup; may vary by batch)
Evaporation Rate: Not established
Flammability: Flammable liquid
Explosion Limits: Data not available
Vapor Pressure: 8–15 mmHg at 25°C
Vapor Density: Heavier than air
Specific Gravity: 1.05–1.10 (at 20°C)
Solubility: Decomposes in water; miscible with most organic solvents
Partition Coefficient (log Kow): Not specified
Autoignition Temperature: Not established
Decomposition Temperature: Decomposes on heating, hydrolyzes in moisture
Viscosity: Not established
Chemical Stability: Unstable in moisture. Stable under dry, cool, and inert conditions.
Reactivity: Reacts with water, acids, and bases to release hydrogen chloride. Exothermic hydrolysis.
Possibility of Hazardous Reactions: Violent reaction with water; forms corrosive vapors.
Conditions to Avoid: Heat, ignition sources, humidity, contact with incompatible materials.
Incompatible Materials: Water, alcohols, strong acids and bases, oxidizers, amines.
Hazardous Decomposition Products: Hydrogen chloride gas, silicon oxides, carbon oxides, organochlorine compounds.
Routes of Exposure: Inhalation, skin absorption, eye contact, ingestion
Acute Toxicity: Toxic if inhaled or swallowed. LD50 (oral, rat): Data not specified but considered harmful at low doses. LC50 (inhalation): Data suggest respiratory tract irritation at low concentrations.
Skin Corrosion/Irritation: Severe skin burns with extended contact
Serious Eye Damage/Irritation: Causes serious, potentially irreversible eye damage
Respiratory or Skin Sensitization: No evidence of sensitization
Chronic Effects: Repeated exposure may affect respiratory system and gastrointestinal tract
Carcinogenicity: Not classified by NTP, IARC, or OSHA; no controlled studies in humans
Mutagenicity/Teratogenicity: No data available
Other Information: Prolonged exposure might aggravate pre-existing skin or respiratory disorders
Ecotoxicity: Harmful to aquatic life due to acidity and reactivity. Exact LC50/EC50 unavailable; avoid release into waterways.
Persistence and Degradability: Undergoes rapid hydrolysis in the environment, forming hydrochloric acid and silanols.
Bioaccumulative Potential: Low; hydrolysis and decomposition products do not persist
Mobility in Soil: Reacts with moisture in soil, does not migrate significantly
Other Adverse Effects: Acidification from hydrolysis products can disturb local aquatic ecosystems.
Waste Treatment Methods: Collect hazardous waste in compliant, labeled containers. Chemical must be fully hydrolyzed and neutralized before disposal.
Disposal of Product: Dispose through a licensed hazardous waste contractor. Follow all local, state, and national regulations.
Disposal of Contaminated Packaging: Rinse thoroughly, puncture, and dispose of as hazardous waste.
Precautions: Do not pour into drains, soil, or sewers.
UN Number: UN2987
UN Proper Shipping Name: Chlorosilanes, flammable, corrosive, n.o.s. (contains 3-chloroisopropyoxysilane)
Transport Hazard Classes: 3 (Flammable liquids), 8 (Corrosive substances)
Packing Group: II
Environmental Hazards: Marine pollutant
Special Precautions: Keep away from moisture, secure container upright, label with hazardous material placards
Regulatory Transport Requirements: Comply with ADR/RID, IMDG, IATA regulations
OSHA: Subject to hazardous chemical regulations
TSCA Inventory: Listed
EPA SARA Title III: Not specifically listed, but general hazardous substance reporting may apply
REACH: Registered or subject to registration where imported into the EU above certain thresholds
Other Applicable Regulations: Refer to country, state, and local chemical safety and labeling standards
