Chemical Name: 3-Chloropropylmethyldiethoxysilane
CAS Number: 13501-76-3
Product Code: Varies by supplier
Synonyms: Chloropropylsilane, Silane, (3-chloropropyl)methyldiethoxy-
Recommended Use: Chemical synthesis, coupling agent, surface modifier
Manufacturer: Refer to supplier documentation for contact information
Emergency Contact: Access local emergency telephone number, Poison Control Center
Address: Refer to product label or purchasing records for manufacturer information
GHS Classification: Flammable Liquids (Category 3), Skin Irritation (Category 2), Eye Irritation (Category 2A), Specific Target Organ Toxicity—Single exposure (Category 3), Aquatic Hazard (Category 2)
GHS Label Elements: Flame, Exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Causes skin and eye irritation. Harmful if inhaled, causes respiratory tract irritation. Toxic to aquatic life with long lasting effects.
Precautionary Statements: Keep away from sources of ignition. Wear protective gloves and goggles. Do not breathe fume, mist, or vapor. Avoid release to the environment.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Pictograms: GHS02 (Flame), GHS07 (Exclamation mark), GHS09 (Environment)
Chemical Name: 3-Chloropropylmethyldiethoxysilane
Molecular Formula: C8H19ClO2Si
Purity: Typically >97%
Impurities: Diethoxymethylsilane (<2%), unknown trace materials
Other Components: None as intended in commercial packaging
General Advice: Remove contaminated clothing and shoes. Seek immediate medical care for any symptoms.
Inhalation: Move the person to fresh air immediately. If breathing has stopped, provide artificial respiration. Consult a physician.
Skin Contact: Wash the affected area with mild soap and plenty of water for at least 20 minutes. Remove and launder clothing.
Eye Contact: Rinse thoroughly with water for at least 15 minutes, holding eyelids open. Remove contact lenses if possible.
Ingestion: Do not induce vomiting. Rinse mouth with water. Never give anything by mouth to an unconscious person. Seek medical attention.
Symptoms of Exposure: Redness, itching, burning sensation, respiratory tract irritation, dry cough, headache
Suitable Extinguishing Media: Dry chemical, alcohol-resistant foam, carbon dioxide, water spray (do not use direct water jet)
Specific Hazards Arising from the Chemical: Unstable under heat or fire conditions. Emits toxic fumes including carbon oxides, hydrochloric acid, silicon oxides
Special Protective Equipment: Wear self-contained breathing apparatus and full protective suit
Fire Fighting Instructions: Withdraw personnel from area, contain run-off. Approach upwind and cool containers with water spray. Prevent fire water from entering drains or surface water systems.
Hazards to Firefighters: Explosive vapors may accumulate in confined spaces
Personal Precautions: Evacuate area. Shut off sources of ignition. Ventilate area. Use personal protective equipment as required.
Environmental Precautions: Prevent further leakage or spillage if safe. Avoid entry into drains, sewers, or water courses.
Spill Response: Absorb with non-combustible, inert materials (e.g. sand, earth, vermiculite). Collect in chemical waste container for disposal. Clean area with detergents, avoid using solvents.
Disposal: Dispose of according to local, regional, national, and international regulations
Handling: Keep the chemical in well-ventilated area. Ground and bond containers during transfer. Employ explosion-proof electrical equipment and local exhaust ventilation. Always use appropriate PPE. Avoid breathing vapor and contact with skin or eyes.
Storage: Store in tightly closed original container. Keep in a cool, dry, well-ventilated place away from sources of ignition, heat, and direct sunlight. Segregate from oxidizers, acids, bases. Avoid prolonged or repeated exposure. Store below 30°C, keep out of reach of unauthorized personnel.
Incompatible Materials: Strong oxidizers, acids, moisture, bases, halogens
Engineering Controls: Process enclosure, local exhaust ventilation, or other engineering controls to keep airborne levels well below recommended exposure limits.
Personal Protective Equipment—Eyes: Chemical safety goggles with side shields
Personal Protective Equipment—Skin: Impervious gloves (nitrile recommended), chemical-resistant apron, long sleeves
Personal Protective Equipment—Respiratory: NIOSH-approved respirator if airborne concentrations exceed exposure limits
Workplace Safety Measures: Handle only in area with emergency shower and eyewash station. Do not eat, drink, or smoke in work area.
Appearance: Clear, colorless to slightly yellow liquid
Odor: Mild, ether-like
Odor Threshold: Not established
pH: Not applicable
Melting Point / Freezing Point: <-60°C
Boiling Point: 211°C at 760 mmHg
Flash Point: 74°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid and vapor
Upper/Lower Flammability Limits: Not determined
Vapor Pressure: 0.6 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 0.94–0.97 g/cm³ at 25°C
Solubility: Insoluble in water; soluble in organic solvents
Partition Coefficient (n-octanol/water): 2.1 (estimated)
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not available
Viscosity: < 5 cSt at 25°C
Chemical Stability: Stable under normal conditions of storage and handling
Conditions to Avoid: Heat, open flame, sparks, static electricity, moisture
Incompatible Materials: Avoid strong oxidizers, acids, bases, water
Hazardous Decomposition Products: Carbon oxides, hydrogen chloride, silicon oxides
Possibility of Hazardous Reactions: Moisture contact leads to hydrolysis and release of hydrochloric acid; vapor may form explosive mixture with air under certain circumstances
Acute Toxicity: LD50 (oral, rat): estimated 300–2000 mg/kg; LD50 (dermal, rabbit): >2000 mg/kg; inhalation data not determined
Skin Corrosion/Irritation: Causes moderate to severe irritation
Serious Eye Damage/Irritation: Causes serious eye irritation
Respiratory Sensitization: Not classified, yet irritation may result from repeated or high exposures
Carcinogenicity: No data indicating carcinogenic effects
Reproductive Toxicity: No evidence reported
Symptoms Related to Exposure: Headache, dizziness, nausea, mucous membrane irritation, eye redness, skin burns (prolonged contact)
Chronic Effects: Prolonged or repeated exposure can produce dermatitis, respiratory symptoms
Mutagenicity: No information available
Other Data: Hydrolysis byproducts can be corrosive
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Undergoes slow hydrolysis in water, but some persistence likely
Bioaccumulative Potential: Potential for bioaccumulation exists in aquatic organisms, data limited
Mobility in Soil: Mobile in soil, especially in organic content rich matrices due to low water solubility
Other Adverse Effects: Toxicology of byproducts including hydrochloric acid should be considered in environmental release scenarios
Aquatic Toxicity: EC50 (fish, daphnia) not precisely established, avoid environmental discharge
Disposal Methods: Incinerate in an approved facility. Avoid landfill disposal unless no better option exists. Absorbed waste should be collected and sealed in appropriate containers.
Packaging Disposal: Triple rinse containers. Offer for recycling, if possible. Dispose of in accordance with official regulations.
Special Precautions: Do not discharge into sewers, drains, or waterways. Comply with all local, regional, and national waste disposal regulations.
Waste Category: Consult local hazardous waste authority for classification and reporting requirements
UN Number: UN 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (3-Chloropropylmethyldiethoxysilane)
Transport Hazard Class: 3
Packing Group: III
Marine Pollutant: Yes
Transport Labels: Flammable liquid (3), Environmentally hazardous
Special Precautions: Keep upright, handle gently, protect from physical damage, ensure container integrity
Regulatory Notes: Not regulated as toxic or corrosive for transport, but flammability and environmental hazard apply
US TSCA: Listed
EU REACH: Registered or pre-registered, subject to restrictions on use and handling
OSHA Status: Regulated as hazardous chemical, with required training and exposure control
WHMIS Classification (Canada): B2—Flammable Liquid; D2B—Toxic Material
SARA 313: Not listed
Inventory Status: Listed on AICS, DSL, EINECS, ENCS, KECI, PICCS, IECSC
Additional Information: Safety, health, and environmental regulations vary by jurisdiction. Employers should refer to all applicable regulations regarding workplace exposure, handling, transport, and environmental release. Review workplace safety standards periodically to include updates in applicable legislation.
