Chemical Name: 3-Glycidyloxypropylmethyldimethoxysilane
Synonyms: (3-Glycidyloxypropyl)methyldimethoxysilane, Glycidoxypropylmethyldimethoxysilane
CAS Number: 65799-47-5
Recommended Uses: Used as an adhesion promoter, surface modifier in coatings and sealants, coupling agent for glass fibers, additive for epoxy and silicone resins
Restrictions: Industrial use only, not for household applications
Manufacturer/Supplier: Product information available from specialty chemical distributors and silica-based product suppliers
Emergency Contact Number: Emergency response support and poison control information available through regional hotlines and manufacturer
GHS Classification: Flammable Liquid (Category 3), Eye Irritation (Category 2A), Skin Irritation (Category 2), Sensitization - Skin (Category 1), Specific Target Organ Toxicity – Single Exposure (Category 3)
Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause allergic skin reaction, may cause respiratory irritation, flammable liquid and vapor, harmful if inhaled
Pictograms: Flame, Exclamation mark
Precautionary Advice: Keep away from heat and open flame, use protective gloves and eye protection, avoid breathing vapors, choose adequate ventilation, wash thoroughly after handling, store in a cool, well-ventilated place
Routes of Exposure: Skin contact, inhalation, eye contact
Long-term Risks: Prolonged or repeated contact may defat skin, increase sensitivity, harmful effects on respiratory system
Chemical Name: 3-Glycidyloxypropylmethyldimethoxysilane
CAS Number: 65799-47-5
Concentration: >95%
Impurities: May contain trace organosilicon byproducts from synthesis, residual solvents
Other Ingredients: No intentional hazardous additives
Inhalation: Move affected person to fresh air promptly, keep warm and at rest, assist breathing with oxygen if necessary, seek medical attention for persistent symptoms
Skin Contact: Immediately remove contaminated clothing, wash skin thoroughly with plenty of soap and water, seek medical attention if skin irritation develops or persists
Eye Contact: Rinse continuously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, obtain medical attention if redness, pain or vision changes occur
Ingestion: Rinse mouth thoroughly, give water to drink, do not induce vomiting unless directed by medical personnel, seek immediate medical assistance for large exposures or if symptoms develop
Most Important Symptoms: Skin redness, itching, swelling, eye redness or watering, difficulty breathing after inhalation, abdominal discomfort after ingestion
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide, water spray for cooling
Unsuitable Extinguishing Media: High pressure water jets may spread fire
Specific Hazards: Flammable vapors may form explosive mixtures with air, thermal decomposition can release toxic fumes including carbon oxides, silicon oxides, and incompletely burned hydrocarbons
Firefighter Protection: Wear full protective gear including positive-pressure self-contained breathing apparatus
Additional Advice: Cool exposed containers with water spray, prevent runoff from fire control from entering sewers or waterways
Personal Precautions: Evacuate unprotected personnel, ensure adequate ventilation, avoid contact with skin and eyes, prevent inhalation of vapors, wear suitable protective equipment such as gloves and eye/face protection
Environmental Precautions: Prevent spillage from entering drains, watercourses, or soil, contain spilled product with inert absorbent materials like sand or earth
Cleanup Methods: Absorb spill with inert material, use spark-proof tools and explosion-proof equipment, transfer waste to suitable, labeled containers for disposal, decontaminate area with detergent and water, ventilate space well
Handling: Only handle with proper protective equipment, ground and bond containers to prevent static discharge, use spark-proof tools, work inside fume hoods or with exhaust ventilation, prevent contact with incompatible substances such as oxidizers and strong acids, avoid generating aerosols
Storage: Store at room temperature away from heat sources and direct sunlight, keep containers tightly closed when not in use, segregate from food and drink, label containers properly, use corrosion resistant shelving and secondary containment if available, regularly inspect for leaks or damage
Special Considerations: Limit access to trained personnel, have emergency eyewash and showers readily accessible, maintain written procedures for emergencies and accidental exposure
Occupational Exposure Limits: No established specific OSHA PEL or ACGIH TLV, consider observing limits for organic vapor exposure
Engineering Controls: Use local exhaust ventilation in areas where vapor or aerosol may be generated, ensure safety showers and eye wash stations are nearby, maintain good general room ventilation, monitor air quality in confined areas
Personal Protection: Wear chemical-resistant gloves (nitrile or butyl rubber recommended), safety goggles or face shields, flame-resistant lab coats or aprons, use of respiratory protection (NIOSH approved respirator) if material is handled in poorly ventilated areas or aerosolized, avoid wearing contact lenses
Hygiene Measures: Wash hands, face and exposed skin thoroughly after handling, change contaminated clothing immediately, do not eat, drink, or smoke in work area
Appearance: Clear to light yellow liquid
Odor: Slight, characteristic odor
Odor Threshold: Not established
pH: Not applicable (nonaqueous)
Melting/Freezing Point: Below -50°C
Boiling Point/Range: Approximately 270°C
Flash Point: 107°C (Closed cup, typical)
Evaporation Rate: Very slow under ambient conditions
Flammability (solid/gas): Not applicable
Upper/Lower Flammability or Explosive Limits: Lower 1.2%, Upper unknown
Vapor Pressure: Less than 1 mmHg at 25°C
Vapor Density: Estimated >1 (air=1)
Relative Density: About 1.05 g/cm³
Solubility: Slightly soluble in water, miscible with most organic solvents
Partition Coefficient (n-octanol/water): No data available
Auto-ignition Temperature: Above 250°C
Decomposition Temperature: Above 250°C
Viscosity: Low, 1-5 cP at 25°C
Chemical Stability: Product remains stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: Vapor may form explosive mixture with air, reacts with water, alcohols, acids to give methanol, uncontrolled polymerization possible if heated or exposed to alkalis
Conditions to Avoid: Heat, sparks, open flames, direct sunlight, static discharge, moisture
Incompatible Materials: Acids, oxidizing agents, strong bases, water
Hazardous Decomposition Products: Methanol, formaldehyde, carbon oxides, silicon oxides
Likely Routes of Exposure: Inhalation of vapor or aerosol, skin absorption, eye contact, accidental ingestion
Acute Effects: Skin and eye irritation, respiratory discomfort, transient central nervous system effects from methanol byproduct, sensitization reactions possible
Chronic Effects: Prolonged or repeated exposure may cause dermatitis, aggravate existing respiratory conditions, possible liver and kidney stress due to methanol exposure
Toxicity Data: Acute oral LD50 (rat): >2000 mg/kg, Dermal LD50 (rabbit): >2000 mg/kg, Inhalation LC50: >5 mg/L (4h, rat, estimated)
Carcinogenic Status: No IARC, NTP, or OSHA listing as human carcinogen
Mutagenicity and Teratogenicity: No confirmed evidence in available studies
Additional Information: Methanol released from hydrolysis is toxic by oral, dermal, and inhalation routes
Acute Aquatic Toxicity: No current evidence for acute toxicity in fish or daphnia at expected environmental concentrations
Chronic Aquatic Toxicity: Low bioaccumulation potential, hydrolyzes to methanol and organosiloxanes in water
Degradability: Expected to be hydrolytically unstable in the environment, forming non-persistent species
Mobility: May migrate through soil, spilled product could leach into groundwater
Persistence: Parent compound not likely to persist, but transformation to methanol and siloxanes occurs rapidly
Other Hazards: Methanol is hazardous to aquatic organisms in elevated concentrations, take steps to prevent release to waterways
Disposal Methods: Collect waste in tightly sealed, labeled containers, dispose of via licensed hazardous waste contractor, incinerate in chemical incinerator equipped with afterburner and scrubber
Container Disposal: Rinse empty containers with suitable solvent, discard as hazardous waste
Local Regulations: Follow all applicable local, regional, and national regulations for disposal of chemical and contaminated packaging
Precautions: Do not drain to sewer, prevent releases to soil or surface waters
UN Number: 1993
Proper Shipping Name: Flammable liquid, n.o.s. (Contains silane derivatives)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Transport Label: Required flammable liquid label
Special Precautions: Secure containers during transport, avoid shipping with incompatible substances, keep away from sources of ignition and extreme temperatures
Marine Pollutant: Not designated as marine pollutant under IMDG
Regulatory Notes: Comply with rules of DOT, IMO, IATA for all modes of shipment
Safety, Health, and Environmental Regulations: Subject to TSCA inventory requirements, may require reporting under SARA Title III (Section 311/312) for hazardous chemicals, ingredients listed in EINECS and ELINCS inventories
Workplace Restrictions: Use in accordance with OSHA standards for hazardous materials and chemical handling
Labelling Requirements: Product label must contain GHS classification pictograms and hazard statements
Risk Phrases: R10 (flammable), R36/38 (irritating to eyes, skin), R43 (may cause sensitization by skin contact)
Precautionary Phrases: P210 (Keep away from heat sources), P261 (Avoid breathing vapor), P280 (Wear protective gloves/eye protection)
Additional National Requirements: Local regulations on air emissions, water discharges, and waste management may apply depending on region
Inventory Information: Present on US TSCA, EU REACH, Australia AICS, Canada DSL, Japan ENCS
