Product Name: 3-Isocyanatopropyltrimethoxysilane
Chemical Formula: C7H15NO4Si
Synonyms: γ-Isocyanatopropyltrimethoxysilane
CAS Number: 15396-00-6
Manufacturer: Contact manufacturer or supplier information listed on bottle/label
Product Use: Industrial organosilicon compound, surface modifier, adhesion promoter
Emergency Contact: Refer to supplier or local health and safety authority for hotline number
Telephone Number for Information: Refer to workplace SDS resource or chemical supplier
GHS Classification: Acute Toxicity (oral, inhalation, dermal), Skin Corrosion/Irritation, Serious Eye Damage, Respiratory Sensitizer, Specific Target Organ Toxicity (Single Exposure)
Pictograms: Health hazard, Exclamation mark, Corrosive
Signal Word: Danger
Hazard Statements: Causes skin burns and serious eye damage. Suspected of causing respiratory irritation. Harmful if inhaled, swallowed, or absorbed through skin.
Potential Health Effects: Eye, skin, and respiratory system irritation; prolonged exposure can cause dermatitis, asthma-like reactions.
Precautionary Statements: Avoid breathing vapors. Wear protective gloves, clothing, and eye or face protection. Use only outdoors or in well-ventilated space.
Chemical Name: 3-Isocyanatopropyltrimethoxysilane
CAS Number: 15396-00-6
Concentration: 98-100%
Impurities: Trace organic solvents or hydrolysis by-products possible from manufacturing or storage; may include methanol at residual levels
Additives: None identified, mixture is considered pure
Inhalation: Move affected person to fresh air. Seek immediate medical attention if breathing becomes difficult. Provide oxygen if available. Do not attempt mouth-to-mouth if substance is inhaled.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with plenty of water for at least 15 minutes. Get medical attention promptly. Thoroughly wash clothing and shoes before reuse.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present. Continue rinsing for a minimum of 15 minutes, hold eyelids open. Do not apply neutralizing chemicals. Get emergency medical help.
Ingestion: Rinse mouth with water. Never induce vomiting. Give water to dilute if victim is conscious. Get medical attention immediately.
Most Important Symptoms: Severe irritation, burns, difficulty in breathing, allergic reactions. Immediate medical attention required for all exposure routes.
Suitable Extinguishing Media: Carbon dioxide, regular dry chemical, foam, or water mist. Do not use direct water stream, chemical can react with water producing hazardous gases.
Special Hazards: Emits toxic fumes of nitrogen oxides, silicon oxides, and isocyanates during combustion. Vapors may form explosive mixtures with air.
Protective Equipment for Firefighters: Full protective suit, self-contained breathing apparatus with positive pressure mode, chemical-resistant gloves, face shield.
Firefighting Instructions: Keep containers cool by spraying with water. Stay upwind. Evacuate area if fire is uncontrolled or if large scale release is possible.
Explosion Data: Vapors may be heavier than air and travel to ignition source; precautions needed against potential reactivity with water or moisture.
Personal Precautions: Evacuate unprotected personnel. Ventilate area. Wear respirator, chemical goggles, gloves, and suit to avoid skin and eye contact. Avoid breathing vapors or dust.
Environmental Precautions: Prevent entry into drains, water courses or soil. Inform authorities if product enters environment.
Methods for Cleanup: Absorb spills with sand, earth, or suitable inert absorbent. Scoop up and place in a closed, labeled container for disposal. Clean area thoroughly with water after containment – remain mindful of exothermic reaction. Remove contaminated waste promptly.
Handling: Avoid inhaling vapor or aerosol. Use splash goggles, impermeable gloves, and chemical-resistant clothing. Ensure local exhaust ventilation. Do not eat, drink, or smoke during handling. Wash hands and face after handling.
Storage: Store in a cool, well-ventilated location with secure closure. Keep away from ignition sources, food, and incompatible substances like oxidizers, strong acids, and water. Protect from moisture. Store away from direct sunlight and sources of heat. Dedicated chemical storage cabinets recommended.
Engineering Controls: Use closed handling systems, local exhaust ventilation, and safety showers or eye wash stations nearby.
Exposure Limits: None established for 3-Isocyanatopropyltrimethoxysilane; treat as isocyanate compound, refer to ACGIH TLV for isocyanates (0.005 ppm ceiling value for monomeric isocyanates).
Personal Protection: Respirator with organic vapor cartridge or supplied air system. Splash goggles, face shield, full suit impervious clothing. Chemical-resistant gloves (nitrile, neoprene, butyl rubber). Avoid contact lenses.
Workplace Hygiene: Remove contaminated clothing before breaks or leaving work. Prohibit eating, drinking, or smoking in work area.
Appearance: Clear, colorless to pale yellow liquid
Odor: Pungent, irritating isocyanate odor
Odor Threshold: Not determined
pH: Not applicable
Melting Point/Freezing Point: Below -20°C
Boiling Point: 195°C (approximate)
Flash Point: 68°C (closed cup method)
Evaporation Rate: Not available
Flammability: Slightly flammable liquid and vapor
Explosive Limits: Lower: Not available; Upper: Not available
Vapor Pressure: Low; less than 1 mmHg at 20°C
Vapor Density: Heavier than air
Specific Gravity: 1.05–1.10 (at 20°C)
Solubility: Reacts with water; soluble in organic solvents (alcohols, ketones)
Partition Coefficient (n-octanol/water): Not established
Auto-ignition Temperature: Not established
Decomposition Temperature: Can decompose with heat and moisture
Viscosity: Not available
Chemical Stability: Stable under recommended storage conditions in original tightly sealed container. Decomposed by moisture and heat.
Hazardous Reactions: Violent reaction with water, alcohols, amines, acids producing carbon dioxide and heat which may rupture sealed containers.
Incompatible Materials: Water, alcohols, amines, acids, oxidizing agents. Reacts vigorously with water and moist air.
Hazardous Decomposition Products: Carbon dioxide, nitrogen oxides, carbon monoxide, silicon oxides, isocyanates (toxic vapors).
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Effects: Burning sensation, shortness of breath, nausea, headache, severe skin and eye irritation. Sensitization possible.
Chronic Effects: Asthma, chronic dermatitis, sensitization to isocyanates. Long-term inhalation may cause irreversible respiratory effects.
Toxicity Data: No specific LD50 or LC50 established for this silane, structurally similar isocyanates show acute toxicity via inhalation and skin absorption.
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA (May be present in formulations containing residual isocyanates, which are suspected carcinogens).
Mutagenicity: Data not available
Reproductive Toxicity: No specific data for this compound; prudent avoidance advised.
Additional Information: Sensitization possible after repeated exposures; cases of occupational asthma reported with isocyanate chemicals.
Environmental Toxicity: No detailed data for this compound. Isocyanates are toxic to aquatic organisms.
Persistence and Degradability: Hydrolyzes in water to amines and methanol; hydrolysis products can be more mobile in the environment.
Bioaccumulative Potential: No significant bioaccumulation expected, based on physical-chemical properties.
Mobility in Soil: Liquid compound likely to migrate through soil after hydrolysis; potential for leaching with water.
Other Adverse Effects: Methanol released on hydrolysis may contribute to groundwater concerns.
Precautions: Avoid direct release into the environment and waterways. Treat spills promptly, follow hazardous waste guidance.
Waste Disposal Methods: Dispose of in accordance with local, regional, national, and international regulations. Incineration in a permitted hazardous waste facility is preferred. Do not discharge to sewer systems.
Container Disposal: Triple rinse empty containers before recycling or disposal. Treat rinsate as hazardous waste.
Precautions: Prevent release into the environment. Label all waste. Consult authorities before discarding residue.
UN Number: 2810
UN Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (3-Isocyanatopropyltrimethoxysilane)
Transport Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Marine Pollutant: Not classified as marine pollutant but avoid environmental release.
Special Precautions: Keep away from food and incompatible materials.
DOT, IATA, IMDG: Follow specific regulations for each mode of transport. Secure packages to prevent leaks.
OSHA Status: Classified hazardous according to OSHA Hazard Communication Standard.
TSCA Inventory: Listed or exempt.
SARA Title III Sections 302/304: Not listed.
SARA Title III Section 313: Isocyanate content may require reporting if used in large volumes.
RCRA Status: Considered hazardous waste if discarded based on characteristics.
California Proposition 65: Methanol, a possible hydrolysis product, listed as reproductive toxin.
EU Classification: Dangerous substance; CLP Regulation applies.
Other Regulations: Always review local, state, and federal laws before handling or disposing.
