Product Name: 3-Thiocyanatopropyltriethoxysilane
CAS Number: 34708-08-2
Synonyms: Triethoxy(3-thiocyanatopropyl)silane
Recommended Use: Organosilane coupling agent for surface modification, adhesion promotion
Supplier Contact Details: Name, address, phone number, emergency contact provided on the product label
Emergency Phone Number: CHEMTREC or local emergency information
Manufacturer Identification: Specific manufacturing site and responsible personnel should be detailed with all corresponding direct lines for reporting issues or chemical exposures
GHS Classification: Acute toxicity (Oral, Dermal, Inhalation), Skin irritation, Eye irritation
GHS Label Elements: Pictogram of exclamation mark, skull and crossbones, and corrosion
Signal Word: Warning
Hazard Statements: Harmful if swallowed, Toxic in contact with skin, Irritating to eyes, Causes skin irritation, May cause respiratory irritation
Precautionary Statements: Avoid contact with skin, eyes, and clothing, Wear protective gloves and goggles, Do not breathe dust, fumes, or vapors, Wash hands thoroughly after handling, Use only outdoors or in a well-ventilated area
Potential Health Effects: Inhalation can cause dizziness, respiratory tract irritation; Skin absorption and contact lead to burns or allergic reactions; Eye exposure causes severe irritation, possible damage; Ingestion results in nausea, abdominal pain, chemical burns
Environmental Risks: Toxic to aquatic life with long-lasting effects; risk of bioaccumulation
Chemical Name: 3-Thiocyanatopropyltriethoxysilane
Chemical Formula: C10H21NOS3i
Concentration: 98–100% pure
Impurities: May contain trace silanol compounds, ethanol (from hydrolysis during storage or application)
Relevant Impurities: Hydrolysis products such as thiocyanate ions, ethanol
EC Number: 253-803-5
Inhalation: Move exposed person to fresh air immediately, monitor breathing, provide respiratory support if breathing difficult, seek immediate medical attention
Skin Contact: Remove contaminated clothing, flush affected skin with water for at least 15 minutes, wash thoroughly with soap and water, do not delay medical treatment for significant exposure
Eye Contact: Rinse open eyes gently with plenty of clean water for a minimum of 15 minutes, remove contact lenses carefully, avoid rubbing or closing eyes, seek medical care
Ingestion: Do not induce vomiting, rinse mouth, give water if conscious and alert, immediate emergency medical attention critical for suspected poisoning or large exposures
Symptoms: Burning sensation, pain, redness, chemical burns, dizziness, headache, shortness of breath, nausea, coughing, abdominal distress
Special Treatment: Provide supportive care as required; administer oxygen and treat symptomatically at healthcare facility
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam, water spray for cooling containers exposed to fire
Unsuitable Extinguishing Media: Direct water jet which can spread the chemical or cause violent boilover
Specific Hazards: Releases toxic fumes of oxides of sulfur, nitrogen, silicon compounds, and possible thiocyanate gases during combustion
Protective Equipment: Chemical protective suit, self-contained breathing apparatus, gloves, goggles
Special Procedures: Evacuate non-essential personnel, avoid inhaling smoke or vapors, contain any runoff used for fire control
Decomposition Products: Hydrogen cyanide, sulfur oxides, nitrogen oxides, silicon dioxide, ethanol vapor
Personal Precautions: Evacuate non-essential personnel, ventilate area, avoid breathing vapors or dust, use personal protective equipment—respirator, chemical-resistant gloves, splash-proof goggles, protective suit
Environmental Precautions: Prevent spillage from entering sewers, waterways or soil; containment barriers and soak up with non-combustible absorbent (sand, earth, vermiculite)
Clean-Up Methods: Remove sources of ignition, use spark-proof tools, collect material in suitable container for proper disposal, wash spill site after removal
Disposal Consideration: Dispose contaminated clean-up material as hazardous waste according to regulatory requirements
Handling: Wear appropriate personal protective equipment, use only in a chemical fume hood or well-ventilated area, avoid contact with skin, eyes, or clothing, prevent inhalation of dust or vapor, do not eat, drink, or smoke during use
Safe Storage: Store in a tightly closed original container, keep out of reach of children and unauthorized personnel, place in a cool, dry, well-ventilated space away from direct sunlight, moisture, incompatible chemicals (e.g. acids, strong oxidizers, amines, water), maintain temperature controls to avoid excessive heat
Storage Incompatibilities: Keep away from oxidizing agents and water; hydrolyzes on contact with water generating flammable ethanol
Specific Storage Requirements: Use corrosion-resistant containers, mark containers clearly, check for leaks or deterioration regularly
Exposure Limits: No established occupational exposure limit for 3-Thiocyanatopropyltriethoxysilane
Engineering Controls: Local exhaust ventilation, safety showers, eyewash stations available in immediate work area
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), full-coverage safety goggles, face shield for splash potential, flame-retardant lab coat, rubber or PVC apron
Respiratory Protection: NIOSH-approved organic vapor respirators or full-face supplied-air respirators for high concentrations
Environmental Exposure Control: Prevent release to environment, use closed systems and secondary containment where feasible
Appearance: Colorless to pale yellow liquid
Odor: Characteristic, sharp odor
Melting Point: Below room temperature
Boiling Point: Approximately 107–110°C at reduced pressure
Flash Point: Around 90°C (closed cup)
Vapor Pressure: Low at standard temperature
Solubility: Decomposes in water; miscible with most alcohols, solvents
Specific Gravity: 1.07–1.10 g/cm³ (20°C)
pH: Not applicable (hydrolyzes in water)
Evaporation Rate: Not rapid, based on comparable silanes
Partition Coefficient (n-octanol/water): Not determined, likely to concentrate in organic phases
Autoignition Temperature: Not specified
Explosive Properties: Not explosive under normal handling, may develop vapors at elevated temperatures
Viscosity: Low viscosity, mobile liquid
Chemical Stability: Stable under recommended storage conditions, decomposes over time in presence of moisture or water
Reactivity: Reacts with water, acids, strong oxidizing agents, amines, producing hazardous byproducts (ethanol, thiocyanate releases, toxic gases)
Hazardous Decomposition Products: Hydrogen cyanide, sulfur oxides, nitrogen oxides, silicon oxides, ethanol
Conditions to Avoid: Moisture, excessive heat, ignition sources, contact with incompatible materials
Polymerization: No hazardous polymerization predicted
Corrosion Potential: Attacks metals in presence of water, can cause corrosion of steel or aluminum containers
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): estimated 200–500 mg/kg; Dermal LD50 (rabbit): estimated 500–1500 mg/kg
Skin Irritation: Causes burns, irritation, possible sensitization
Eye Irritation: Causes severe irritation, may result in vision impairment
Respiratory Sensitization: Vapors may cause respiratory tract irritation and allergic response in sensitized individuals
Chronic Effects: Prolonged or repeated exposure may damage skin, respiratory tract, nervous system due to thiocyanate formation
Carcinogenicity: No data available for classification; not listed by IARC, NTP, or OSHA
Mutagenicity: Not evaluated fully
Reproductive Toxicity: Information not available, handle with precaution
Target Organ Effects: Central nervous system, liver, kidneys at high exposures
Symptoms of Exposure: Headache, dizziness, nausea, vomiting, allergic skin reactions, redness, chemical burns, impaired coordination
Toxicity to Aquatic Life: Harmful to aquatic organisms, possible risk of long-term adverse effects due to persistence of thiocyanates and silane byproducts
Persistence and Degradability: Not easily biodegradable; breakdown products may concentrate in water and soil
Bioaccumulation Potential: Likelihood of bioaccumulation in aquatic organisms through thiocyanate moiety
Mobility in Soil: May leach to groundwater, especially with spills in moist environments
Other Environmental Effects: Potential for water contamination, toxic to algae and daphnia in laboratory studies
Disposal to Sewer: Avoid release to drains, improper disposal can result in environmental hazard and toxicity to sewage treatment microbes
Waste Disposal: Must follow federal, state, and local regulations for hazardous waste; incinerate in chemical incinerator with afterburner and scrubber, do not landfill or burn in open air
Disposal of Containers: Triple rinse with compatible solvent, crush or puncture container, dispose as hazardous chemical waste
Precautions: Prevent contact with soil and water, avoid discharge to environment
Special Instructions: Consult with licensed chemical waste disposal contractor for large-scale quantities
UN Number: UN 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 3-Thiocyanatopropyltriethoxysilane)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II or III, depending on quantity and concentration
Labels Required: Toxic substance, marine pollutant if shipped by sea
Special Transport Precautions: Secure all containers upright and labeled; transport only in approved containers; ensure temperature control to prevent leaks or labeling loss
Additional Information: Ensure compliance with ICAO/IATA for air shipment, IMDG for ocean shipment, and DOT (U.S.) regulations for road and rail
OSHA: Regulated as a hazardous chemical under the OSHA Hazard Communication Standard
TSCA Inventory Status: Listed
SARA Title III Section 313: Not subject to reporting, but local regulations may require notification for storage and releases
REACH: Registered under applicable ECHA regulations for use in the EU
California Proposition 65: Not listed as a carcinogen or reproductive toxicant, monitor for updates
Other International Regulations: Covered under various workplace safety and chemical management laws in Japan, Canada (WHMIS Controlled Product), South Korea, Australia
Label Statements: All containers must bear GHS-compliant labeling with hazard statements, pictograms, and precautionary information
