Product Name: 8-Glycidoxyoctyltrimethoxysilane
Synonym: γ-Glycidoxy-n-Octyltrimethoxysilane
Recommended Use: Organic silane coupling agent, functional additive for coatings, adhesives, and sealants
Cas Number: 65799-47-5
Manufacturer: Chemical solutions suppliers, specialty materials manufacturers
Emergency Contact: Refer to national poison control center or local chemical safety authorities
Contact Phone: Listed on shipping label or manufacturer documentation
Classification: Flammable liquid (Category 3), skin irritant (Category 2), eye irritation (Category 2A), sensitizer (Category 1 based on epoxy group)
Hazard Symbols: GHS02 (Flame), GHS07 (Exclamation mark), GHS08 (Health hazard)
Signal Word: Warning
Hazard Statements: Causes skin irritation, may cause allergic skin reaction, causes serious eye irritation, flammable liquid and vapor
Precautionary Statements: Avoid breathing vapor, wear protective gloves/eye protection, wash thoroughly after handling, keep away from ignition sources, ground and bond containers
Chemical Identity: 8-Glycidoxyoctyltrimethoxysilane
Purity: >95%
Impurities: Methanol (trace, produced by hydrolysis), epoxy ring by-products (trace), silicon dioxide (trace)
Relevant Components: Organosilane backbone, glycidyl group, octyl chain, three methoxy substituents bound to silicon
Inhalation: Remove to fresh air. Seek medical attention if breathing becomes difficult, symptoms persist, or coughing occurs.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Seek medical attention if irritation develops.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do. Continue rinsing. Immediate medical attention helps to prevent damage.
Ingestion: Do not induce vomiting. Rinse mouth with water provided the person is alert. Seek medical help immediately.
Advice for Physician: Treat symptomatically, monitor for allergic or respiratory response, provide supportive care as needed
Suitable Extinguishing Media: Carbon dioxide, dry chemical, alcohol-resistant foam
Unsuitable Extinguishing Media: Water jets, which may spread the fire rather than control it
Hazardous Combustion Products: Carbon oxides, silicon oxides, formaldehyde, toxic fumes
Protective Equipment: Firefighters should wear self-contained breathing apparatus and chemical protective clothing
Other Advice: Move containers away from fire area if it can be done without significant risk, cool containers with water mist to reduce heat and vapor pressure buildup
Personal Precautions: Evacuate unnecessary personnel, ventilate area, use personal protective equipment with proper gloves and eye protection
Environmental Precautions: Prevent from reaching waterways, drains, soil. Alert local authorities if spill poses environmental threat
Containment and Clean-up Methods: Soak up small spills with inert absorbent (sand, earth), transfer to secure containers for disposal. Decontaminate area with detergent and water
Handling: Work in well-ventilated areas, avoid vapor inhalation and direct contact with skin or eyes, keep away from open flame and spark sources
Storage: Store in tightly closed containers in cool, dry, and ventilated areas, always keep below 30°C. Store separately from oxidizers, acids, and bases. Protect against moisture, as hydrolysis can generate methanol which increases hazard
Other Considerations: Label containers clearly, implement spill containment plans, keep out of reach of untrained personnel
Occupational Exposure Limits: None established for 8-Glycidoxyoctyltrimethoxysilane, but methanol by-product (TWA 200 ppm, STEL 250 ppm, ACGIH)
Engineering Controls: Use local exhaust ventilation and closed processes to minimize vapor exposure
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), tightly fitting safety goggles, flame-retardant lab coats, chemical splash-resistant footwear
Hygiene Measures: Wash hands before eating or drinking, remove and clean contaminated clothing promptly, avoid eating in work areas
Appearance: Clear, colorless to pale yellow liquid
Odor: Mild, ether-like
Odor Threshold: Not determined
pH: Not applicable (non-aqueous liquid)
Melting Point: <-20°C
Boiling Point: 305°C at 760 mmHg
Flash Point: 105°C (closed cup)
Evaporation Rate: Comparable to lower molecular weight organosilanes
Flammability: Flammable
Vapor Pressure: 0.05 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 1.02 g/cm³ at 25°C
Solubility: Reacts with water (hydrolyzes), soluble in organic solvents like ethanol, toluene, acetone
Partition Coefficient (Log Pow): Not determined
Auto-ignition Temperature: 370°C
Decomposition Temperature: No data available
Viscosity: 8-12 mPa.s at 25°C
Chemical Stability: Stable under recommended storage conditions, sensitive to humidity and moisture
Reactivity: Hydrolyzes in the presence of water, releasing methanol
Possibility of Hazardous Reactions: May react exothermically with strong acids or bases, generates methanol under wet conditions
Incompatible Materials: Strong oxidizers, acids, bases, moisture, water
Hazardous Decomposition Products: Methanol, formaldehyde, silicon oxides, carbon oxides
Routes of Exposure: Inhalation, dermal contact, ingestion, and eye contact
Acute Toxicity: Oral LD50 (rat) >2000 mg/kg. Inhalation and dermal toxicity expected to be low due to high molecular weight and low volatility, though irritation and sensitization can occur
Skin Corrosion/Irritation: Causes skin irritation; repeated contact can enhance allergic responses
Serious Eye Damage/Irritation: Causes pronounced eye irritation, redness, tearing, and discomfort
Respiratory Sensitization: Not fully established, but glycidyl moiety warrants caution
Carcinogenicity: No conclusive evidence, not classified by IARC or NTP
Reproductive Toxicity: No data available
Target Organ Effects: Prolonged or repeated exposure may impact skin, respiratory system
Chronic Effects: Sensitization possible with repeated exposure
Aquatic Toxicity: Data on 8-Glycidoxyoctyltrimethoxysilane limited; silanes generally considered moderately hazardous to aquatic life due to hydrolysis products (e.g., methanol)
Persistence and Degradability: Undergoes slow biodegradation; hydrolyzes in moist environments forming silanols and methanol
Bioaccumulative Potential: Not expected to bioaccumulate significantly; high molecular weight and rapid hydrolysis reduce risk
Mobility in Soil: Hydrolyzed product binds to soil particles, parent compound may move if released in large quantity
Other Adverse Effects: Polluting waterways may result in fish kill and loss of invertebrate populations; silanols can affect sediment binding
Waste Treatment Methods: Collect into properly labeled, sealed containers for chemical waste. Consult national regulation—typically requires high-temperature incineration with flue gas treatment to remove silicon and organic byproducts
Unused Product: Handle as hazardous chemical waste, follow institutional and national chemical waste instructions
Contaminated Packaging: Rinse thoroughly then dispose according to local hazardous waste protocols
Precautions: Keep away from sewers, surface or groundwater sources
UN Number: 1993 (Flammable liquids, n.o.s.)
UN Proper Shipping Name: Flammable Liquid, N.O.S. (contains glycidoxysilane)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Label: Flammable liquid symbol
Environmental Hazards: Not a marine pollutant under IMDG, but spills into water should be avoided
Special Precautions: Secure containers upright, use protective drums, comply with national and international shipping standards (IATA/ICAO, IMDG, ADR/RID)
US Regulations: TSCA-listed, subject to workplace safety provisions under OSHA Hazard Communication Standard, SARA 311/312 (Fire and Acute Health Hazard). California Proposition 65 could apply if significant formaldehyde present
EU Regulations: REACH registered, classified under CLP Regulation as flammable and irritant, subject to workplace safety notification and use conditions
Other International: Complies with GHS classification, regulated for import/export in Canada, Australia, Japan, Korea under chemical safety laws
Label Elements: GHS pictograms required, safety phrases in local languages, hazard and precaution statements for workplace use
