Back in the postwar chemical boom, researchers worked overtime in search of better ways to bond things—rubber to metal, plastics to glass, and just about everything to silicon. Bis[3-(Trimethoxysilyl)Propyl]Amine came out of those decades of relentless experimentation, as the market pushed for silane coupling agents that didn’t just stick but also withstood heat, moisture, and everyday abuse. Looking at the patents filed in the late twentieth century, it’s easy to see a pattern: the demand for flexible, tough, and chemical-resistant materials forced chemists to blend organic and inorganic chemistry in ways that, frankly, saved industries millions. Today’s products still stand on the shoulders of that early work.
Ask anyone in advanced manufacturing about silane coupling agents, and Bis[3-(Trimethoxysilyl)Propyl]Amine always turns up. This chemical isn’t just a bridge between two worlds—organic and inorganic—it’s also one of those compounds that revolutionized surface modification in paints, plastics, adhesives, and sealants. Its molecular setup grabs tightly onto both silica-packed surfaces and organic matrices, which helps it toughen up everything from aerospace adhesives to sporting equipment. Chemists grew to rely on it because it solved old problems of peel and separation, making products last longer and perform better.
In its pure form, Bis[3-(Trimethoxysilyl)Propyl]Amine pours pale yellow or clear, bringing a fishy, amine-type odor. Standard conditions put its boiling point at about 290°C; the flash point, just above 110°C, keeps safety engineers sharp and attentive. Moisture transforms some of its groups into sticky silanols, binding to a host of inorganic surfaces. Its density sits just a hair above water, showing why it flows so reliably in industrial usage. Unlike some silanes, you won’t see it evaporate quickly, which means less wastage and more control over curing in manufacturing lines.
A quick glance at any supplier’s data sheet shows purification rates above 97%. Labels list out the chemical structure, CAS number (1760-24-3), and recommended storage rules: cool, dry, sealed tight. Weight per mole lands at around 294 grams, and documentation almost always includes refractive index and viscosity, vital for process control. Those technical numbers separate high-quality product from inconsistent batches, and meeting those specifications answers to both performance guarantees and regulatory scrutiny.
Synthetic routes for Bis[3-(Trimethoxysilyl)Propyl]Amine often work with an aminosilane and a simple alkoxysilane, usually in alcohol solvents with acid scavengers on hand. In an industrial context, controlling water is key—too much leads to premature hydrolysis, turning a valuable product into a sticky waste. I’ve seen production managers spend hours fine-tuning the temperature and stirring speeds, just to keep particles from aggregating. It isn’t glamorous, but a clean product history tells you plenty about company discipline and attention to detail.
Anyone modifying surfaces with Bis[3-(Trimethoxysilyl)Propyl]Amine knows to expect a fast reaction with water, forming strong siloxane bonds and slotting amine groups into position for further functionalization. Add the right catalyst, and this compound bonds to glass, ceramics, metals—sometimes even stubborn plastics. Every lab seems to have their trick, tweaking pH or adding curing agents to balance speed against control. Modifiers and crosslinkers pair especially well here, plugging gaps in industrial coatings or running interference against environmental attacks.
This chemical goes by several tongue-twisters, and suppliers aren't shy about adding their own branding spin. The most common aliases pop up as Bis(trimethoxysilylpropyl)amine, BTMSPA, or TwinSilane A-1120 in trade catalogs. Naming changes fast in regulatory filings or in global markets—sometimes it appears with alternate hyphenation, sometimes rolled up into proprietary blends that only chemical sales reps could love.
Every time a drum of Bis[3-(Trimethoxysilyl)Propyl]Amine arrives in a loading bay, the safety paperwork comes next. I remember the time someone on the floor cut open a container without gloves—a weeklong rash followed, and we all doubled down on the PPE reminders. Eye and skin contact stays right up at the top of hazard warnings, especially since splashes or fumes tend to sneak up when lines run fast. Regulatory frameworks from OSHA to REACH flag it for responsible storage—away from acids, with fans running, and clearly labeled secondary containment. Industrial processes live or die by those routines, and the companies that cut corners find out the hard way.
Bis[3-(Trimethoxysilyl)Propyl]Amine shows up wherever companies need their materials to hold together. In automotive assembly lines, it acts as a primer, letting paints and glues stick to glass and metals. Electronics engineers trust it to help etched circuit boards keep their layering through heat cycles. Even dental and orthopedic manufacturers pick it for biocompatible adhesives. Over decades, its role in epoxy and polyurethane systems expanded, since a single batch can treat hundreds of kilos of filler or fiber. Every year, you see new patents for specialty coatings, thanks to the chemical’s stubborn resistance to moisture and its flexibility for further modification.
University and industrial grants keep Bis[3-(Trimethoxysilyl)Propyl]Amine in the spotlight for emerging composites and nano-materials. Some research teams jazz it up with custom side chains, aiming to tweak thermal stability or increase compatibility with new polymers. I hear from colleagues who run experiments on recycling or circular chemistry, betting that silane-treated materials might lend themselves to greener end-of-life processes. One promising avenue involves building smart surfaces—ones that change under stimulus or even optimize themselves during production—in fields from microelectronics to medicine.
Toxicologists scrapped any illusions about chemical safety decades ago. Studies across animal models and cell cultures mapped out the irritancy and sensitization potential for Bis[3-(Trimethoxysilyl)Propyl]Amine, raising flags for skin and respiratory contact. Regulatory filings stack up for workplace exposure, and most plants mandate local exhausts, splash shields, and strict inventory accounting. Wastewater treatment gets special attention, since incomplete hydrolysis could impact local ecosystems. Thoughtful stewardship in processing and disposal limits harm without holding back innovation.
Innovation in materials science always comes down to what building blocks can deliver the most—strength, longevity, adaptability, and sustainability. Bis[3-(Trimethoxysilyl)Propyl]Amine sits in a sweet spot, offering up chemistry that plays well with evolving needs in green tech, biomedical devices, and high-performance engineering. Efforts in bio-based and renewable silane chemistry nudge the market toward safer, even cleaner alternatives. As more data rolls in from R&D partnerships, the compound’s future probably rests on a blend of regulatory compliance, lifecycle analysis, and the drive for smarter, lighter, and more durable products. Each new application raises the bar a bit higher, demanding chemical companies keep pushing for better—and safer—results.
Take a good look at any modern piece of electronics, construction material, or even a wind turbine blade, and you’ll probably find some chemistry designed to make things stick together more reliably. Bis[3-(Trimethoxysilyl)Propyl]Amine—let’s call it by its short name, a silane coupling agent—isn’t famous outside the lab, but plenty of things fall apart without it. I’ve handled enough epoxy repairs and waterproofing jobs to know what happens when surfaces just won’t bond, and this compound doesn’t mess around in that department.
Picture glass fiber mats inside a boat hull, or a lightweight composite used for a car hood. They get their strength not from the fibers alone, but from the tight handshake between the fibers and whatever resin surrounds them. Bis[3-(Trimethoxysilyl)Propyl]Amine forms those bonds by bridging the gap between two worlds: it connects mineral-based surfaces (like silicon in glass or stone fillers) with organic materials (such as epoxy or polyurethane resins). Engineers aren’t just trying to get two things to stick—they want a bond that stands up to vibration, water, heat, and years of wear.
I remember once trying to bond glass beads into a polymer for a research project, using a bargain-brand resin. The result looked fine for a week, then it sagged and pulled apart. When we treated the beads with a silane, the new samples held tight, took a beating, and didn’t fail. That lesson stuck: surface chemistry isn’t just for researchers; it keeps real-world products together.
The push for lighter, tougher materials is everywhere. In the construction world, complex facades, sealed joints, and insulating panels all benefit from silanes. Wind turbine blades reach over fifty meters, flexing in punishing weather, and all the layers rely on persistent bonds. Electronics call for adhesion and insulation in small, delicate packages. Bis[3-(Trimethoxysilyl)Propyl]Amine fits those needs by forming strong links without adding unnecessary weight or risk.
There’s more: companies eye sustainability and worker safety, so they look for chemicals that boost performance with lower toxicity. This silane scores well in that department when compared with older organosilicon-based options. It also repels water, which matters in flood-prone infrastructure and outdoor installations. In my own house, I sealed a basement crack with a product using this compound and, years later, it stays dry—proof that small chemical details make a big difference.
Some resins don’t play well with common adhesives. Flexible plastics or tough ceramics seem impossible to stick. Bis[3-(Trimethoxysilyl)Propyl]Amine breaks through those limits because it brings an amine group, letting it connect with resins that normally shrug off glue. This means new product designs can combine materials manufacturers avoided in the past.
Research keeps finding ways to use this compound more effectively. Scientists test lower concentrations to cut costs or explore water-based processes to reduce emissions. The technology has roots in old-school chemistry, but it keeps cropping up in advanced projects everywhere. If you care about longer-lasting products and cleaner manufacturing, it’s smart to keep an eye on what silane technology does next.
Bis[3-(Trimethoxysilyl)Propyl]Amine works as a staple in laboratories and manufacturing. You see it in silane treatments and used for surface modification. Its structure lets it bond with both inorganic surfaces like glass and organic polymers, so it acts as an excellent adhesion promoter. My years working with silanes have shown that its shelf life and proper function depend less on the fanciness of the facility and more on simple, consistent habits.
Moisture ruins a lot of chemicals, but with silanes—especially this one—you get an ugly surprise if you ignore the warnings. This molecule goes through hydrolysis, meaning water breaks it down. Left open to humid air, you find a solid crust on the bottle neck faster than you think. I learned early to always recap the bottle and store it with fresh desiccant. Even a few moments exposed lets the air start a slow reaction. Dry, room-temperature storage isn't just a label suggestion. It keeps the chemical clear and functional, preventing hydrolyzed byproduct buildup that impacts later results.
Most labs want room temperature, but not all rooms feel the same. On hot summer days, attic-level storage or shelves by windows can tip above 30°C. Higher heat speeds up unwanted reactions and sometimes even causes pressure inside the container. I've opened bottles after a hot weekend only to find the contents clumping or discolored. Find a cool, shaded spot. If you work in a part of the world where seasons swing wildly, insulated cabinets or climate-controlled rooms save materials and money. Chemical suppliers set a typical upper temperature limit at about 25°C because stability really does taper off above that.
Original packaging is not just for branding; it supplies an essential barrier. Silane-based compounds, especially those with amine groups, are sensitive and sometimes reactive. Manufacturers bottle these in airtight, moisture-resistant containers. Switching bottles or leaving the lid loose causes waste and lowers purity. I once topped off a partly used silane with a generic cap, and it turned chalky in a week—almost $300 gone. Keep the original closure mechanism or use equivalent materials rated for chemical compatibility. Never store in low-quality plastic or reused jars, as they can let in air and break down over time.
This chemical doesn’t have a sharp odor or color that signals danger, leading folks to underestimate its hazards. Splash it on bare hands or inhale the vapors, and you open the door to headaches, skin irritation, or worse. Ventilated workspaces protect lungs. I always keep gloves and goggles right by my workbench. If a spill happens, clean up quick with absorbents, and never use water; water just kicks the reaction into overdrive. A small spill today can mean hours of cleaning sticky resin tomorrow.
Old or tainted material needs responsible disposal. Local regulations often require special treatment because silanes break down into methanol and other unwanted byproducts. Don’t dump them in regular waste. Follow chemical waste protocols. Keeping good records of purchase date and use helps identify aging stock before it causes problems. I mark my bottles with opening dates and scan shelves every few months. Small actions like this let me avoid supply interruptions and expensive do-overs in the lab.
A little vigilance in storing and handling Bis[3-(Trimethoxysilyl)Propyl]Amine gives reliable application and safe workspaces. Well-maintained habits respect the health of workers and the pocketbooks of purchasing managers. Science rewards preparation, and so does this chemical.
Walking into a lab and opening a bottle of chemicals like Bis[3-(Trimethoxysilyl)Propyl]Amine always tells a story. You spot the faint smell in the air, watch a clear liquid spread across a workbench, and a little voice in your head reminds you: do not take shortcuts with silanes. Experienced researchers know: exposure to many organosilanes causes irritation, headaches, and worse if care slips. The number one rule? Personal protection sits at the top of the list. Nitrile gloves, a decent lab coat, and splash-proof goggles matter much more than comfort or style. If you get even a drop on your bare skin, a burning or stinging sensation usually follows. One mistake fast-tracks a trip to the eyewash or the emergency shower. It helps to remember stories from colleagues who ended up visiting the on-site nurse after an avoidable splash.
Good ventilation keeps you out of trouble with chemicals like this. Anyone pouring or mixing Bis[3-(Trimethoxysilyl)Propyl]Amine outside a working fume hood is asking for trouble. Silanes release methanol as they cure—methanol fumes can sneak into the bloodstream through the skin or nose and cause dizziness, drowsiness, or even blurred vision. Spend long enough breathing the stuff without a hood, and you will notice symptoms by the end of your shift. At one academic lab in my early days, nobody thought twice about propping up a sash “just for a minute”; after an accidental spill, three people ended up with splitting headaches. It only takes once.
Fast cleanup matters. Small spills call for absorbent pads and a good soak-down with mild detergent. Avoid sweeping dry material into a dustpan—these powders and liquids like to climb the inside of your nose. Working with silanes changes the way you think about storing bottles. Always keep the container tightly sealed since ambient moisture starts breaking down the chemical, releasing vapors you do not want in the air. Cool, dry cabinets away from sources of water or strong acids keep things a lot safer.
Trash cans are not the place to discard leftover Bis[3-(Trimethoxysilyl)Propyl]Amine. Disposal rules come from local and national authorities—ignoring them lands an entire lab in hot water, sometimes with fines or shutdowns. Labeling all chemical waste, keeping solvents and silanes in separate drums, and signing off paperwork feels tedious at times, but experience tells you spills get traceable fast in a well-run workspace. Professional waste contractors handle the end of the road. Rushing or cutting corners risks an untraceable stink, or worse, a reaction that means fire.
Everybody working with Bis[3-(Trimethoxysilyl)Propyl]Amine benefits from solid training. People talk about PPE and fume hoods, but real safety happens when those habits stick. Veterans teach newer faces how to spot condensation inside a container or the greasy fingerprint of a contaminated glove. I have seen panels up in common areas with stories of close calls, serving as honest reminders of the stakes. No one wants to learn hard lessons twice. Supervisors who push for regular training and simple checklists contribute to a culture where everyone’s health stands above the pressure to finish a synthesis on time.
Bis[3-(Trimethoxysilyl)Propyl]Amine doesn’t appear on the home shelf—it's something you bump into in labs, R&D centers, or places mixing up advanced coatings and adhesives. If you’ve ever splashed any silane on lab gloves, you probably sensed its strong, lingering odor and tacky feel. This stuff brings high reactivity, so simple disposal doesn’t cut it.
A lot of people don’t realize that handling organosilanes is not just about personal safety. Fumes from spills catch in the back of the throat. Left unchecked, residues migrate into groundwater. The hydrolysis products don’t just vanish; they stick around and grab on to soil particles—hard to track, harder to remove. Studies warn that silane exposure causes skin and eye burns, with headaches and sore throat not far behind. Local wildlife shares the risk, especially if runoff brings even small quantities into a nearby creek.
Disposal guidelines don’t exist just for paperwork. In the US, the EPA and OSHA spell out how to treat these specialty chemicals. Just pouring leftover Bis[3-(Trimethoxysilyl)Propyl]Amine down a sink isn’t only reckless—it sets you up for a fine, and worse, a public health hazard. Most city sewer lines can’t handle the breakdown products. Even landfill operators push back if you show up with non-hardened residues.
Putting on goggles and gloves feels routine after a while, but treating leftovers takes real planning. Unused or spent amine silanes belong in tightly sealed, labeled containers—ideally ones that resist corrosion. Don’t mix with general trash or water; the fumes and leachate spread farther than you think. Fire risks jump when silanes mix with strong oxidizers, so storing away from acids and bleach isn’t just a suggestion.
Once in the right container, the next stop is a licensed hazardous waste facility. These centers treat silanes through incineration, using high temperatures to break them down completely. Even rags or pipette tips that touched the chemical go in the hazardous waste bucket, not the everyday bin. Some small labs tag a drum, store it until full, and call certified pick-up companies every couple months.
Any chemist or lab manager worth their salt learns to plan reactions so there’s as little leftover as possible. Before ordering, checking stock and sharing bottles between groups keeps unnecessary purchases down. Pre-weighing only what the procedure calls for helps too—no leftover honey-colored puddle waiting for disposal. Training every new person in the lab with a walk-through reduces mistakes that lead to spills or contamination.
Suppliers sometimes accept unopened containers back, if they’ve been stored right. Don’t keep old, crusty bottles “just in case”—once labels fade or dates disappear, disposal only grows trickier.
Some companies experiment with alternative coupling agents that offer lower toxicity or easier cleanup. If you work somewhere large enough, teaming up with your EHS officer or environmental committee usually uncovers new disposal vendors or recycled material options.
Chemical waste isn’t just a lab issue. Treating Bis[3-(Trimethoxysilyl)Propyl]Amine as serious business helps keep workers safe and groundwater clean. It also keeps scientific workplaces in the good books with local regulators and neighbors. Planning ahead, using personal experience, and sticking to legal disposal channels preserves health and trust—inside the lab and out in the community.
Bis[3-(Trimethoxysilyl)propyl]amine stands out through its two distinct arms, each featuring a trimethoxysilyl group linked to a central amine via a three-carbon propyl bridge. Picture a nitrogen atom holding hands with two propyl chains, and each of those ends in a silicon atom. The silicon atom itself ties up with three methoxy groups—oxygen connected to a methyl group—forming a clear and defined pattern in the molecule.
The full chemical formula lies in the arrangement: C12H31NO6Si2
The kind of chemistry at play here balances both organic and inorganic influences. The “trimethoxysilyl” part connects to a world of silane coupling agents, which make or break bonds between different materials. The propyl chain gives flexibility, and the central amine brings in reactive nitrogen. In a rough rendering, the setup looks like this:(CH3O)3Si–(CH2)3–NH–(CH2)3–Si(OCH3)3. Each trimethoxysilyl group—(CH3O)3Si—anchors itself on the ends, linked through a linear propyl (three carbon) chain to the single nitrogen in the center.
I remember working hands-on with silane coupling agents in a lab full of glassware and busy researchers. The way these molecules behave never fails to impress. The dual trimethoxysilyl arms make this particular compound a master connector. On one end, it binds strongly to silica or glass surfaces, thanks to the silane chemistry. On the other, the propyl amine link in the middle offers a place for organic chemistry to happen.
In adhesives, sealants, rubber—anything that has to bring together incompatible fronts—bis[3-(trimethoxysilyl)propyl]amine plays a role that people rarely see but always appreciate in the finished product. The name reads like a tongue-twister, but the chemistry delivers results. That central amine doesn’t just sit around; it takes part in crosslinking reactions, especially in silicone rubbers or epoxy formulations. Surface modification scientists prize this amine for setting up strong, durable bonds.
Problems show up in industry when adhesion fails, or materials never quite mix well. This molecule helps solve that. It brings together surfaces that don't want to mix—glass with resin, or mineral fillers with polymer matrices. In my work, adding this to a composite material led to a finish that shrugged off water and held up longer under stress.
Engineers often face tough combinations, say, glass fibers inside a plastic part. Here, relying on molecules with firm attachment points—like bis[3-(trimethoxysilyl)propyl]amine—leads to better products. Silanes like this also enable surface treatments. After cleaning a glass surface thoroughly, a chemist applies a silane solution. The trimethoxysilyl groups crosslink with surface hydroxyls, while the amine can capture additional molecules or link into a curing network. This technique turns a smooth, unreactive surface into one that grabs tight to whatever comes next.
People working with bis[3-(trimethoxysilyl)propyl]amine discover there’s more than just a fancy name. This molecule connects the dots between wet chemistry and real-world materials. As someone who’s seen the disappointment of failed layers peeling apart and the pride of smooth, tough surfaces that stay put, I find this chemistry hard to beat.
![Bis[3-(Trimethoxysilyl)Propyl]Amine](/static/26ffdaf2-b05a-4718-b9a8-e71fecc06434/images/2d/bis-3-trimethoxysilyl-propyl-amine.png)
![Bis[3-(Trimethoxysilyl)Propyl]Amine](/static/26ffdaf2-b05a-4718-b9a8-e71fecc06434/images/3d/bis-3-trimethoxysilyl-propyl-amine.gif)
| Names | |
| Preferred IUPAC name | N¹,N¹-Bis[3-(trimethoxysilyl)propyl]methanamine |
| Other names |
Bis[3-(trimethoxysilyl)propyl]amine Aminobis(trimethoxysilylpropyl) 3-(Trimethoxysilyl)propylamine bis N-[3-(Trimethoxysilyl)propyl]-3-(trimethoxysilyl)propan-1-amine BTMSPA |
| Pronunciation | /ˈbɪs θri traɪˈmiθɒksiˌsɪlaɪl ˈproʊpəl əˈmiːn/ |
| Identifiers | |
| CAS Number | 1760-24-3 |
| Beilstein Reference | 1462309 |
| ChEBI | CHEBI:80813 |
| ChEMBL | CHEMBL3724393 |
| ChemSpider | 25232564 |
| DrugBank | DB11224 |
| ECHA InfoCard | ECHA InfoCard: 100.034.506 |
| EC Number | 69591-87-3 |
| Gmelin Reference | 1238896 |
| KEGG | C19300 |
| MeSH | D017209 |
| PubChem CID | 102112 |
| RTECS number | KH8445000 |
| UNII | BZ429R911A |
| UN number | UN3334 |
| CompTox Dashboard (EPA) | DTXSID5020663 |
| Properties | |
| Chemical formula | C18H45N O6Si2 |
| Molar mass | 493.82 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Odor | Amine-like |
| Density | 1.01 g/mL at 25 °C |
| Solubility in water | Soluble |
| log P | 1.5 |
| Vapor pressure | <1 mmHg (20°C) |
| Acidity (pKa) | 10.2 |
| Basicity (pKb) | 6.7 |
| Magnetic susceptibility (χ) | -7.36E-6 cm³/mol |
| Refractive index (nD) | 1.428 |
| Viscosity | 5 cP (25 °C) |
| Dipole moment | 1.3007 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 668.6 J·mol⁻¹·K⁻¹ |
| Pharmacology | |
| ATC code | '' |
| Hazards | |
| Main hazards | Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| GHS labelling | GHS07, GHS05 |
| Pictograms | GHS05, GHS07 |
| Signal word | Warning |
| Hazard statements | Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| Precautionary statements | P261, P264, P271, P272, P280, P302+P352, P321, P332+P313, P362+P364, P501 |
| NFPA 704 (fire diamond) | 1-1-0 |
| Flash point | > 145 °C |
| Lethal dose or concentration | LD50 Oral Rat 2000 mg/kg |
| LD50 (median dose) | LD50 (median dose): Oral, Rat: > 2,000 mg/kg |
| NIOSH | Not Listed |
| PEL (Permissible) | '1 ppm' |
| REL (Recommended) | 50 ppm |
| Related compounds | |
| Related compounds |
Bis[3-(Triethoxysilyl)propyl]amine 3-(Trimethoxysilyl)propylamine N-(2-Aminoethyl)-3-aminopropyltrimethoxysilane Bis(trimethoxysilylpropyl)ethylene N-[3-(Trimethoxysilyl)propyl]ethylenediamine |
