Product Name: Methoxytrimethylsilane
Chemical Formula: C4H12OSi
Synonyms: Trimethylmethoxysilane, Silane, methoxytrimethyl-
CAS Number: 992-16-1
Recommended Use: Chemical synthesis, laboratory reagent, surface treatment agent
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GHS Classification: Flammable Liquid, Category 2; Acute Toxicity (inhalation), Category 4; Skin Irritation, Category 2; Eye Irritation, Category 2A
Label Elements: Danger, Flame symbol, Exclamation mark
Hazard Statements: Highly flammable liquid and vapor; Harmful if inhaled; Causes skin irritation; Causes serious eye irritation
Precautionary Statements: Keep away from heat, sparks, open flames; Avoid breathing vapor; Wear protective gloves, eye protection
Potential Health Effects: Inhalation may cause respiratory irritation and headaches; Skin contact leads to redness and dryness; Eyes may water and redden; Prolonged contact brings greater risk of health impacts
Chemical Name: Methoxytrimethylsilane
Concentration: 98% or greater
CAS Number: 992-16-1
Impurities: May include trace levels of related silanes or methanol; concentration varies by manufacturer, typically less than 2%
General Advice: Move affected person to fresh air promptly
Inhalation: Remove casualty to fresh air, loosen clothing, support breathing
Skin Contact: Remove contaminated clothing quickly, rinse skin thoroughly with running water for at least 15 minutes
Eye Contact: Flush eyes immediately under running water for 15 minutes; lift eyelids often
Ingestion: Rinse mouth, do not induce vomiting, seek medical attention
Advice to Physicians: Treat symptoms, monitor respiration closely
Extinguishing Media: Use alcohol-resistant foam, dry chemical, or carbon dioxide; avoid direct water streams
Specific Hazards: Produces toxic and flammable fumes on burning; vapor may form explosive mixture with air
Protective Equipment: Full-face self-contained breathing apparatus; fire-resistant clothing
Special Procedures: Cool containers exposed to heat using water spray; avoid breathing fumes
Personal precautions: Remove ignition sources, ventilate area, wear chemical-resistant gloves, splash-proof goggles
Environmental precautions: Prevent spillage from entering drains, watercourses, and soil
Cleanup methods: Absorb using inert material like vermiculite or dry sand, place in chemical waste container for disposal
Safe Handling: Work in well-ventilated area, ground all handling equipment, avoid inhalation and skin exposure, use anti-static protective clothing
Storage Conditions: Keep tightly closed in original container, store in a cool, dry, well-ventilated place away from heat and ignition sources
Incompatible Materials: Strong oxidizers, strong acids, alkalis; contact with moisture produces methanol
Exposure Limits: No occupational exposure limits established for methoxytrimethylsilane; monitor related methanol exposure (TWA 200 ppm, ACGIH)
Engineering Controls: Use mechanical exhaust or local ventilation; maintain compartment seals
Personal Protective Equipment: Nitrile or neoprene gloves, chemical splash goggles, flame-resistant lab coat
Respiratory Protection: Air-purifying respirator with organic vapor cartridge if ventilation is inadequate
Hygiene Measures: Wash hands immediately after handling; avoid eating or drinking in work area
Appearance: Clear, colorless liquid
Odor: Ether-like smell
Odor Threshold: Not established
pH: Not applicable
Melting Point: -76°C (-104.8°F)
Boiling Point: 57°C (135°F)
Flash Point: -2°C (28°F) (closed cup)
Evaporation Rate: Fast
Flammability: Highly flammable
Vapor Pressure: 177 mmHg at 20°C
Vapor Density: 3.5 (air = 1)
Relative Density: 0.75 g/cm³
Solubility: Slightly soluble in water; mixes with organic solvents
Partition Coefficient (n-octanol/water): Not determined
Auto-Ignition Temperature: 200°C (392°F)
Decomposition Temperature: Not determined
Viscosity: Low, flows easily
Explosive Properties: May form explosive vapor-air mixtures
Oxidizing Properties: Not an oxidizer
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Reacts with water to form methanol and trimethylsilanol
Conditions to Avoid: Heat, flame, sparks, static discharge, excess moisture
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases, water (generates methanol on contact)
Hazardous Decomposition Products: Methanol, formaldehyde, carbon oxides, silicon oxides
Acute Toxicity: Inhalation studies in lab rats show LC50 of about 23,000 mg/m³ for 4 hours
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Skin Corrosion/Irritation: Causes moderate irritation
Serious Eye Damage/Irritation: Can cause severe eye redness and watering
Respiratory/Skin Sensitization: No evidence of sensitization from available data
Specific Target Organ Toxicity: May depress nervous system; methanol byproduct particularly hazardous
Chronic Effects: No long-term studies, but related silanes shown to affect respiratory system by repeated exposure
Carcinogenicity: Not classified as carcinogenic
Reproductive Toxicity: None reported
Ecotoxicity: Limited data, but siloxane derivatives persist and bioaccumulate in aquatic environments
Persistence and Degradability: Not readily biodegradable
Bioaccumulative Potential: Medium; can be taken up by aquatic species
Mobility in Soil: Spills move quickly through soil, risk to groundwater
Other Adverse Effects: Hydrolysis in water yields methanol and silanol, both with toxic profiles in higher concentrations
Waste Disposal Methods: Dispose of as hazardous organic waste through licensed disposal contractor
Contaminated Packaging: Container must be triple-rinsed; then treated as hazardous waste
Special Instructions: Do not allow material to drain into sewers, ground, or water sources
Regulations: Complete disposal according to local, regional, and national requirements; contact appropriate regulatory authority for disposal advice
UN Number: UN 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (includes Methoxytrimethylsilane)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Labels Required: Flammable Liquid label
Special Transport Precautions: Keep packages upright and securely closed; keep away from heat, sparks, open flames during transit
Regulation Listings: Substance included in TSCA inventory in the USA; regulated under REACH in the EU (consult SDS for registration status)
Workplace Labelling: Required in all working environments in compliance with OSHA or EU-CLP standards
Other Applicable Regulations: SARA Title III, CERCLA listed for methanol byproduct; reportable quantity over 5000 lbs
Right-to-Know Laws: Methoxytrimethylsilane and methanol listed in state inventories such as California Proposition 65
Special Restrictions: Use limited to professionals trained in hazardous chemical handling; environmental release must comply with permitted levels according to local, state, and regional laws
