Product Name: N-(2-Aminoethyl)-3-Aminoisobutylmethyl-Dimethoxysilane
Chemical Formula: C10H26N2O2Si
CAS No.: 18058-42-1
SYNONYMS: AEADMS, 3-(Methylamino)isobutyl-2-(aminoethyl)dimethoxysilane
Recommended Use: Coupling agent, surface modifier for industrial and research settings
Manufacturer: Contact manufacturer or supplier listed on your original purchase documents
Contact Information: Refer to supplier’s emergency contact or safety officer for further directions
Classification: Acute Toxicity—Oral (Category 4); Skin Corrosion/Irritation (Category 2); Eye Damage/Irritation (Category 1); Sensitization, Skin (Category 1)
Label Elements: Corrosive pictogram, GHS07, GHS05
Signal Word: Danger
Hazard Statements: Harmful if swallowed; Causes severe skin burns and eye damage; May cause an allergic skin reaction
Precautionary Statements: Avoid breathing mist/vapors; Use personal protective equipment; Wash thoroughly after handling; Contaminated clothing should not be allowed out of the workplace
Chemical Name: N-(2-Aminoethyl)-3-Aminoisobutylmethyl-Dimethoxysilane
CAS Number: 18058-42-1
Concentration: > 98% by weight
Impurities: Trace silane byproducts, less than 1%, nonhazardous
Inhalation: Move affected person outside to fresh air; keep warm and at rest; seek medical attention if symptoms continue
Skin Contact: Remove contaminated clothing; immediately flush skin with plenty of water for at least 15 minutes; seek medical evaluation for burns
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses where possible, keep rinsing; consult an ophthalmologist
Ingestion: Rinse mouth and do not induce vomiting; give water if the person is fully conscious; contact poison control and a medical professional
Most Important Symptoms: Burns, red skin, eye pain, respiratory irritation—see a doctor in any case of exposure
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide—avoid water jet
Special Hazards: Vapors can produce toxic gases including nitrogen oxides, carbon monoxide, silicon dioxide, and oxides of silicon; containers may burst under fire
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective clothing; stay upwind of fire
Advice for Firefighters: Evacuate danger area; use spray to cool exposed containers; prevent runoff from entering sewers or watercourses
Personal Precautions: Wear chemical-resistant gloves, goggles, respirators, and protective clothing; evacuate unnecessary personnel
Environmental Precautions: Stop spill from entering drains, surface or ground water
Methods for Cleanup: Absorb spilled material with inert absorbent (e.g. vermiculite or sand); collect for disposal in appropriate closed container; ventilate the area; decontaminate affected surfaces with dilute acid if safe
Handling: Use only inside well-ventilated chemical fume hoods; avoid skin or eye contact and inhalation of vapor or mist; wear suitable gloves, safety glasses, and laboratory coats
Storage Conditions: Store locked up inside tightly closed original containers at 2–8°C away from direct sunlight and moisture; keep away from food and incompatible materials (strong oxidizers, acids, bases); label all storage vessels with chemical name and hazard symbols
Control Parameters: No specific TLV or PEL set; minimize all exposures due to significant health hazard
Engineering Controls: Immediate area should have eyewash station and emergency shower access; use chemical fume hoods
Respiratory Protection: Wear properly fitted NIOSH/MSHA-approved respirator during cleaning up large spills or handling outside containment
Eye Protection: Use chemical splash goggles with full face shield
Skin Protection: Long chemical-resistant gloves, impervious body covering, laboratory apron; replace gloves frequently
Hygienic Measures: Wash hands after handling, remove contaminated clothing and wash before reuse, avoid eating or drinking around product
Appearance: Clear to pale yellow liquid
Odor: Characteristic, amine-like
Odor Threshold: Not established
pH (neat): 10–12
Melting Point/Freezing Point: Below -30°C
Boiling Point: 250–265°C
Flash Point: 105°C (open cup)
Evaporation Rate: Not determined
Flammability: Combustible liquid
Vapor Pressure: <0.1 mmHg at 20°C
Vapor Density: >1 (air=1)
Solubility: Hydrolyzes in water, partially soluble
Partition Coefficient (n-octanol / water): Not available
Auto-ignition Temperature: >250°C
Decomposition Temperature: Not established
Viscosity: 1–3 cST at 25°C
Chemical Stability: Stable under recommended storage and handling procedures
Reactivity: Hydrolyzes on contact with water, generating methanol and silanols
Hazardous Reactions: Contact with acids or oxidizers accelerates decomposition
Conditions to Avoid: Humidity, strong oxidizers and acids, open flames, ignition sources
Hazardous Decomposition Products: Methanol, formaldehyde, nitrogen oxides, silicon oxides, methylamine
Polymerization: Product does not polymerize under normal handling conditions
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): 800 mg/kg; skin irritation (rabbit): causes burns; eye damage (rabbit): causes irreversible damage
Symptoms: Reddening, pain, blistering, cough, shortness of breath, eye watering, ulceration
Chronic Effects: Repeated or prolonged skin contact may cause dermatitis, sensitization possible
Carcinogenicity: Not classified as carcinogen under IARC, NTP, ACGIH standards
Mutagenicity/Teratogenicity: No current evidence for mutagenic or reproductive toxicity; precaution warranted
Other Data: Methanol byproduct—risk of systemic toxicity on hydrolysis; avoid all exposure without protective measures
Aquatic Toxicity: Very toxic to aquatic organisms; data limited but expected to cause long-term harm to aquatic environments if released in quantity
Persistence and Degradability: Hydrolyzes rapidly on contact with water to smaller fragments; siloxanes may persist in environment
Bioaccumulation Potential: Does not significantly bioaccumulate due to breakdown, but local concentrations may pose risk
Mobility: High—may leach through soil, particularly in moist conditions
Other Adverse Effects: Byproducts such as methanol and amines have known aquatic toxicity; avoid discharge into environments without treatment
Waste Treatment Methods: Dispose through licensed waste disposal contractor, incinerate or chemically neutralize in controlled facility
Contaminated Packaging: Containers and residues should be triple rinsed, punctured, and sent for licensed disposal
Sewage Disposal: Do not dispose into sewers, waterways, or environment; follow all regional regulations
Special Notes: Contact local hazardous waste authorities for guidance on chemical neutralization if on-site treatment is required
UN Number: UN 2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (contains N-(2-Aminoethyl)-3-Aminoisobutylmethyl-Dimethoxysilane)
Transport Hazard Class: 8
Packing Group: II
Environmental Hazards: Dangerous to aquatic environments, keep away from waterways
Transport Labels: Corrosive, Marine Pollutant
Special Transport Precautions: Protect from moisture and sunlight, carry documentation of emergency spill and first aid instruction
Regulatory Status: Subject to chemical regulations for handling, use, reporting, and disposal in many countries
Inventory Listings: TSCA (USA), EINECS/ELINCS (EU), DSL/NDSL (Canada), ENCS (Japan), AICS (Australia), KECI (Korea)
Labeling Requirements: Comply with OSHA Hazard Communication Standards, GHS requirements
Restrictions: Not permitted for unrestricted consumer or public sale; for trained professionals in controlled environments
SARA Title III: Not listed as a reportable chemical
Other Regulatory Info: Local, state, and regional rules may be more restrictive than federal or international regulations; always consult legal department for compliance
