Product Name: N-(2-Aminoethyl)-3-Aminopropyltriethoxysilane
Synonyms: APTES; Silane, N-(2-aminoethyl)-3-aminopropyltriethoxy-
CAS Number: 1760-24-3
Recommended Use: Coupling agent; commonly used for surface modification, adhesion promotion, and functionalization in industries like coatings, adhesives, and composites
Manufacturer Contact: Emergency phone numbers accessible through Chemtrec or local authorities for chemical emergencies
Address: Check on supplier’s documentation for correct and up-to-date address
Prepared by: Technical and Regulatory Affairs Team, trained in hazard communication and chemical safety
GHS Classification: Skin Corrosion/Irritation (Category 1B); Serious Eye Damage/Irritation (Category 1); Acute Toxicity Oral (Category 4); Acute Toxicity Inhalation (Category 4)
Label Elements: Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; harmful if swallowed or inhaled; may cause respiratory irritation
Pictograms: Corrosive, Exclamation Mark
Precautionary Statements: Avoid breathing dust, fume, gas, mist, vapors, spray; wash hands thoroughly after handling; wear protective gloves, clothing, and eye protection; do not eat, drink or smoke when using this product
Chemical Name: N-(2-Aminoethyl)-3-Aminopropyltriethoxysilane
Chemical Formula: C8H22N2O3Si
Molecular Weight: 222.36 g/mol
CAS Registry Number: 1760-24-3
Impurities: Substance is typically supplied above 98% purity; small residual contaminants may come from production but do not alter primary hazards
Inhalation: Move person to fresh air immediately; loosen tight clothing; seek medical advice if symptoms like coughing, shortness of breath, or irritation occur
Skin Contact: Remove contaminated clothing; rinse skin with plenty of running water for at least 15 minutes; use mild soap if available; seek medical attention for any irritation or burns
Eye Contact: Rinse eyes slowly and gently with water for at least 15 minutes keeping eyelids open; remove contact lenses if present and easy to do; immediate medical attention necessary
Ingestion: Rinse mouth thoroughly; do not induce vomiting; give small quantities of water; seek immediate medical assistance even if no symptoms are present
Suitable Extinguishing Media: Use alcohol-resistant foam, carbon dioxide, dry chemical, or water spray; water jets may not be efficient because of spread
Unsuitable Media: Avoid high-pressure water streams, which might promote splattering
Specific Hazards: Product may emit toxic fumes of nitrogen oxides, carbon oxides, silicon oxides, and hydrogen chloride on combustion or thermal decomposition
Protective Equipment for Firefighters: Full body protective clothing and self-contained breathing apparatus required due to risk of toxic gases
Advice for Firefighters: Keep containers cool with water spray; evacuate area as necessary; avoid inhalation of decomposition products
Personal Precautions: Wear chemical-resistant gloves, protective clothing, and goggles; ventilate area well; prevent skin, eye, and respiratory exposure
Environmental Precautions: Keep product away from drains, waterways, and soil to prevent environmental contamination; inform local authorities in case of significant spill or release
Methods for Containment: Absorb spilled material with inert materials like sand, earth, or vermiculite; transfer to appropriate containers for disposal
Cleaning Up: Use non-sparking tools; wash spill area with water once absorbed material is removed; prevent further release by sealing containers properly and storing securely
Handling: Use only in well-ventilated areas; open containers slowly and carefully; avoid contact with eyes, skin, and clothing; wash hands before eating, drinking, or smoking; ensure all equipment is grounded
Storage: Keep containers tightly closed in a cool, dry, well-ventilated location; store away from acids, bases, and strong oxidizing agents; separate from food and drink items; protect from moisture, since hydrolysis occurs over time
Incompatible Materials: Acids, bases, strong oxidizers, moisture, and humid air
Other Practices: Label storage areas and containers clearly; keep emergency spill cleanup materials nearby; regularly inspect storage areas for leaks or corrosion
Occupational Exposure Limits: No specific limits established by OSHA or ACGIH; handle as a hazardous chemical
Engineering Controls: Local exhaust ventilation or fume hood essential for indoor use; emergency eyewash stations and safety showers in the work area
Personal Protective Equipment: Eye protection with safety goggles; chemical resistant gloves (nitrile or neoprene suggested); lab coat or apron; if splashing likely, use face shield; in insufficient ventilation, approved respirator for organic vapors recommended
Hygiene Measures: Wash hands after handling and before meals or breaks; change contaminated clothing and wash before reuse; seek medical support for exposure concerns
Appearance: Clear to pale yellow liquid
Odor: Ammonia-like, fishy
Odor Threshold: Not readily available
pH: Alkaline (in water)
Melting Point/Freezing Point: < -70°C
Boiling Point/Range: 217°C at 1013 hPa
Flash Point: 93°C (closed cup)
Evaporation Rate: No specific data provided; expected to evaporate slowly
Flammability: Not classified as flammable, but vapor may be combustible at higher temperatures
Vapor Pressure: < 0.01 hPa at 20°C
Vapor Density: >1 (Air = 1)
Density: 0.946 g/cm³ at 20°C
Solubility: Hydrolyzes in water, soluble in organic solvents
Partition Coefficient (n-octanol/water): Not readily available
Auto-Ignition Temperature: >200°C
Decomposition Temperature: Not specified
Viscosity: ~2.5 mPa.s at 25°C
Chemical Stability: Stable in original unopened containers under recommended storage conditions; exposure to moisture over time leads to hydrolysis and release of ethanol
Conditions to Avoid: Exposure to moisture, high temperatures, open flames, and sources of ignition; contact with acids and bases
Incompatible Materials: Moisture, acid chlorides, anhydrides, oxidizers, strong acids, and strong bases
Hazardous Decomposition Products: Ethanol, nitrogen oxides, carbon dioxide, and silicon oxides under fire or strong heat
Polymerization: Not expected under normal process conditions
Routes of Exposure: Inhalation, ingestion, and skin/eye contact
Acute Toxicity: Oral LD50 (rat): 2995 mg/kg; Dermal LD50 (rabbit): > 2000 mg/kg
Inhalation: May cause respiratory irritation, coughing, and certain CNS effects at high concentrations
Skin/ Eye Contact: Contact causes burns, severe irritation, redness, and possible prolonged injury
Chronic Effects: Long-term exposure might cause adverse effects on respiratory system and skin
Sensitization: Not expected under recommended use but severe reactions possible if mishandled
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Other Data: Data from humans limited largely to accidental industrial exposures; appropriate PPE and careful procedures limit risk
Aquatic Toxicity: Harmful to aquatic organisms at higher concentrations; specific LC50/EC50 not widely published
Persistence and Degradability: Hydrolyzes in water to produce ethanol and silanol, which further condenses; ethanol is readily biodegradable
Bioaccumulative Potential: Unlikely to bioaccumulate due to hydrolysis and transformation
Mobility in Soil: Mobility increases with water; hydrolysis products migrate in groundwater
Other Adverse Effects: Avoid uncontrolled releases; substance may affect aquatic environments through pH shifts and organosilicon residues
Waste Handling: Treat as hazardous waste; collect and transfer to certified chemical disposal company
Disposal Methods: Incinerate under controlled conditions in accordance with local, regional, and national regulations
Contaminated Packaging: Rinse containers thoroughly before disposal or recycling; manage rinsate as hazardous; do not reuse containers for other materials
Sewage Disposal: Do not release to drains, sewers, or waterways
UN Number: UN2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (Contains N-(2-Aminoethyl)-3-Aminopropyltriethoxysilane)
Transport Hazard Class: 8 (Corrosive)
Packing Group: II
Environmental Hazards: Not classified as a marine pollutant
Special Precautions for Users: Ensure packages are intact, properly labeled, and handled by trained staff; follow documentation requirements for all regulatory bodies involved (DOT, IATA, IMDG)
OSHA: Listed as hazardous chemical per 29 CFR 1910.1200 Hazard Communication Standard
TSCA: Appears on the US EPA TSCA Inventory
SARA Title III: Section 311/312: Acute health hazard
State Regulations: Check local and state hazardous substance lists for reporting and handling requirements
REACH (Europe): Registered under REACH for production/importation in EU; safety data supplied by European Chemical Agency
Other Regulatory Listings: Check with national agencies (WHMIS in Canada; GHS in other countries) for workplace safety practices
