Substance Name: N-(2-Aminoethyl)-3-Aminopropyltrimethoxysilane
Synonyms: 3-(Trimethoxysilyl)-N-(2-aminoethyl)propylamine
CAS Number: 1760-24-3
Recommended Use: Organosilane coupling agent, surface modifier, adhesion promoter
Supplier Information: Supplier’s address, phone number, emergency contact number
Product Code: Provided by supplier
Classification: Corrosive to skin and eyes; harmful if swallowed; may cause respiratory irritation
Hazard Statements: Causes severe skin burns and serious eye damage; harmful by inhalation, ingestion, skin contact; potential to irritate respiratory system
Precautionary Statements: Avoid inhalation of vapors, fumes, or mists; use only outdoors or in well-ventilated area; wear protective gloves, clothing, and eye protection at all times
Signal Word: Danger
Pictograms: Corrosive, Exclamation mark
Routes of Exposure: Inhalation, ingestion, skin, eye contact
Symptoms: Burning sensation, coughing, pain, redness, blistering, eye damage
Chemical Name: N-(2-Aminoethyl)-3-Aminopropyltrimethoxysilane
CAS Number: 1760-24-3
Concentration: ≥97% by weight
Impurities: Trace methanol, trace water, organic by-products
Inhalation: Remove to fresh air immediately; seek medical attention for breathing difficulty or irritation
Skin Contact: Remove contaminated clothing; wash affected areas with soap and water for at least 15 minutes; seek medical advice for persistent irritation
Eye Contact: Rinse eyes cautiously with plenty of water for at least 15-20 minutes, occasionally lifting both upper and lower eyelids; remove contact lenses if present and easy to do; seek urgent medical help
Ingestion: Rinse mouth with water; do not induce vomiting; do not give anything by mouth to an unconscious person; seek immediate medical attention
Note to Physicians: Treat symptomatically; consider possible exposure to corrosive or irritant substances
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Media: Direct water jet due to risk of spreading chemical
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, silicon oxides, formaldehyde, toxic fumes
Protective Equipment: Self-contained breathing apparatus, full protective gear, chemical-resistant boots and gloves
Firefighting Procedures: Move containers from fire area if possible without risk, use water spray to cool containers, avoid inhaling vapors or fumes
Fire/Explosion Hazard: Vapors heavier than air, may travel along ground; closed containers may rupture if exposed to fire or extreme heat
Personal Precautions: Use personal protective equipment including respirator, gloves, goggles; avoid skin and eye contact; evacuate unnecessary personnel
Environmental Precautions: Prevent further leakage or spillage if safe; keep chemical out of drains, sewers, and waterways
Containment Methods: Stop leak if safe; use non-combustible absorbent materials (sand, earth, vermiculite) to soak up spill; collect in appropriate containers for disposal
Cleanup Methods: Ventilate area; clean contaminated surface thoroughly; dispose of collected material according to local regulations; wash spill area with soap and water
Handling: Only handle in well-ventilated areas; avoid breathing vapors, fumes, or mists; do not eat, drink, or smoke during use; wear assigned PPE including gloves, eye/face protection, and clothing; wash hands thoroughly after handling; prevent contact with skin, eyes, and clothing; use only with adequate ventilation
Storage Conditions: Store in tightly sealed original container, in a dry, cool, well-ventilated area, away from sources of ignition, heat, direct sunlight, and incompatible materials; protect from moisture to prevent hazardous reaction; keep out of reach of children; do not store near food, beverages, or feed
Incompatibilities: Avoid contact with strong oxidizers, acids, and water/moisture due to risk of hydrolysis and methanol release
Occupational Exposure Limits: No recognized occupational exposure limit for the product itself; consider methanol by-production (OSHA PEL: 200 ppm)
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits
Personal Protective Equipment:
- Eye Protection: Safety goggles with side shields and face shield for splash risk
- Hand Protection: Impervious gloves (nitrile, rubber)
- Clothing: Long-sleeved lab coat or chemical resistant apron
- Respiratory Protection: NIOSH/MSHA-approved respirator if engineering controls do not maintain safe vapor levels
Hygiene Measures: Wash hands and face thoroughly after handling; change contaminated clothing and launder before reuse
Appearance: Clear to pale yellow liquid
Odor: Ammonia-like
Odor Threshold: Not determined
pH: Not determined (hydrolyzes in water)
Melting Point/Freezing Point: Approx. -56°C
Boiling Point: Approx. 261°C
Flash Point: 145°C (closed cup)
Evaporation Rate: Not available
Flammability: Not classified as flammable, but combustible
Explosion Limits: Not available
Vapor Pressure: 0.007 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 1.02 - 1.04 (water = 1)
Solubility: Reacts with water; miscible with organic solvents (alcohols, ketones)
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Decomposes before boiling
Chemical Stability: Stable under expected storage conditions
Hazardous Reactions: Hydrolyzes upon exposure to moisture or water; generates methanol and silanol
Conditions to Avoid: Exposure to moisture, strong acids/bases, oxidizing agents, high heat, ignition sources
Hazardous Decomposition Products: Methanol, silicon oxides, nitrogen oxides, amines, carbon oxides, formaldehyde
Polymerization: Hazardous polymerization will not occur under normal handling
Acute Toxicity: Ingestion and inhalation may cause severe irritation and corrosion; oral LD50 (rat) estimated at 2295 mg/kg; no reliable inhalation LC50
Skin Corrosion/Irritation: Causes burns and blistering
Eye Damage/Irritation: Severe damage and possible blindness with direct contact
Respiratory Sensitization: Potential to irritate respiratory system
Skin Sensitization: Prolonged or repeated exposure may cause dermatitis
Chronic Effects: Prolonged or repeated exposure can exacerbate existing respiratory, skin, and eye diseases; long-term risk for organ damage not fully established
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity: No reliable data
Reproductive Toxicity: Not established
Other Information: Metabolism may yield methanol, a known toxicant
Ecotoxicity: Toxic to aquatic life with long lasting effects; LC50 (96 h, fish) >100 mg/L; EC50 (48 h, daphnia) 81 mg/L
Persistence and Degradability: Slowly hydrolyzes in water to form silanols and methanol; methanol is biodegradable, silanols less so
Bioaccumulative Potential: Low; methanol may exhibit some potential but rapidly degrades
Mobility in Soil: Hydrolysis products may leach to groundwater
Other Adverse Effects: Avoid release to environment, product dangerous to aquatic organisms and plants
Disposal Methods: Dispose of in accordance with federal, state, and local environmental control regulations; do not discharge to drains, soil, or surface water
Product Disposal: Incinerate in approved chemical incinerator with afterburner and scrubber; neutralize before discharge
Container Disposal: Triple rinse; destroy by controlled incineration or as hazardous waste
Precautions: Ensure containers remain tightly sealed; never reuse empty packaging for food or drink purposes
UN Number: 2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (N-(2-Aminoethyl)-3-Aminopropyltrimethoxysilane)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Marine Pollutant: Yes
Special Precautions for Transport: Use corrosion-resistant containers; segregate from foodstuffs; follow all carrier and regulatory standards
Labels: Corrosive symbol required on all packaging and documentation
TSCA Status: Listed in TSCA Inventory
SARA Title III: Not an extremely hazardous substance; section 311/312 hazard categories: acute, chronic, immediate health hazard
OSHA Hazard Communication: Meets criteria for hazardous chemical, mandates labeling and safety practices
EU REACH Registration: Registered and regulated; subject to specific restrictions
Canada DSL/NDSL: Listed
Other Regulations: Refer to regional, national, and local regulations for additional requirements regarding manufacture, distribution, and use
